ArticleHeart rhythm2020
Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia.
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In one paragraph
Article in Heart rhythm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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27citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Guideline
- Modulated Calcium Homeostasis and Release Events Under Atrial Fibrillation and Its Risk Factors: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Exploring the role of CaMKII in exercise-induced cardioprotection.Human cell · 2026Review
- Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation.Annual review of pharmacology and toxicology · 2026Review
- Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes.JACC. Basic to translational science · 2025Article
- Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch.Frontiers in physiology · 2025Article
- NaInternational journal of molecular sciences · 2024Article
- Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy.American journal of physiology. Heart and circulatory physiology · 2024Article
- Late sodium current in synergism with CaPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Dual-chamber ICD for left bundle branch area pacing: the cardiac resynchronization and arrhythmia sensing via the left bundle (cross-left) pilot study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation.Biomedicines · 2022Review
- Cardiac Remodelling Following Cancer Therapy: A Review.Cardiovascular toxicology · 2022Review
- Ziprasidone Induces Rabbit Atrium Arrhythmogenesis via Modification of Oxidative Stress and Sodium/Calcium Homeostasis.Biomedicines · 2022Article
- Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias.International journal of molecular sciences · 2022Review
- Review
- Calcium and Heart Failure: How Did We Get Here and Where Are We Going?International journal of molecular sciences · 2021Review
- Regulatory mechanism of calcium/calmodulin-dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review).Experimental and therapeutic medicine · 2021Review
- Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes.Journal of cardiovascular development and disease · 2021Review
- Phospho-ablation of cardiac sodium channel NaInternational journal of obesity (2005) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Amara Greer-ShortThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio.
Hassan MusaThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Katherina M AlsinaCardiovascular Research Institute, Departments of Molecular Physiology & Biophysics, Medicine (Cardiology), Pediatrics (Cardiology), and Neuroscience, Center for Space Medicine, Baylor College of Medicine, Houston, Texas.
Li NiCardiovascular Research Institute, Departments of Molecular Physiology & Biophysics, Medicine (Cardiology), Pediatrics (Cardiology), and Neuroscience, Center for Space Medicine, Baylor College of Medicine, Houston, Texas.
Tarah A WordCardiovascular Research Institute, Departments of Molecular Physiology & Biophysics, Medicine (Cardiology), Pediatrics (Cardiology), and Neuroscience, Center for Space Medicine, Baylor College of Medicine, Houston, Texas.
Julia O ReynoldsCardiovascular Research Institute, Departments of Molecular Physiology & Biophysics, Medicine (Cardiology), Pediatrics (Cardiology), and Neuroscience, Center for Space Medicine, Baylor College of Medicine, Houston, Texas.
Daniel GratzThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio.
Cemantha LaneThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio.
Mona El-RefaeyThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Sathya UnudurthiThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio.
Michel SkafThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Ning LiThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Physiology & Cell Biology, The Ohio State University College of Medicine, Columbus, Ohio.
Vadim V FedorovThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Physiology & Cell Biology, The Ohio State University College of Medicine, Columbus, Ohio.
Xander H T WehrensCardiovascular Research Institute, Departments of Molecular Physiology & Biophysics, Medicine (Cardiology), Pediatrics (Cardiology), and Neuroscience, Center for Space Medicine, Baylor College of Medicine, Houston, Texas.
Peter J MohlerThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Physiology & Cell Biology, The Ohio State University College of Medicine, Columbus, Ohio; Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio.
Thomas J HundThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio; Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio. Electronic address: Thomas.Hund@osumc.edu.
The Ohio State University Wexner Medical Center · USBaylor College of Medicine · USThe Ohio State University · US
Funding
Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5MDefining novel mechanisms for human arrhythmiaR35HL135754 · NHLBI · OHIO STATE UNIVERSITY · PI MOHLER, PETER J. · 2017 to 2023
$6.0MTargeting the Arrhythmogenic Sources of Human Atrial FibrillationR01HL135109 · NHLBI · OHIO STATE UNIVERSITY · PI Vadim V Fedorov · 2017 to 2026
$6.0MIntegration of structure and signaling in cardiac pacemaker functionR01HL115580 · NHLBI · OHIO STATE UNIVERSITY · PI FEDOROV, VADIM V · 2013 to 2021
$4.2MRegulation of Sarcoplasmic Reticulum Calcium Release in Heart FailureR01HL091947 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2009 to 2019
$3.2MDefining novel mechanisms for regulation of atrial INa and arrhythmiasR01HL134824 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY, MOHLER, PETER J. · 2017 to 2020
$3.0MDetermining the Role of Junctophilin-2 in Cardiac DiseaseR01HL117641 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2014 to 2017
$2.3MCaMKII-dependent regulation of cardiac excitabilityR01HL114893 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2012 to 2016
$1.9MSpectrin-based regulation of cardiac remodeling and heart failureR01HL135096 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2017 to 2020
$1.6MDefining new pathways for cardiac automaticityK99HL146969 · NHLBI · OHIO STATE UNIVERSITY · PI EL REFAEY, MONA · 2019 to 2020
$194kNHLBI NIH HHS K99 HL146969NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL091947NHLBI NIH HHS R01 HL114893NHLBI NIH HHS R01 HL115580NHLBI NIH HHS R01 HL117641NHLBI NIH HHS R01 HL134824NHLBI NIH HHS R01 HL135096NHLBI NIH HHS R01 HL135109NHLBI NIH HHS R35 HL135754
Abstract
backgroundAtrial fibrillation (AF) is the most common type of arrhythmia. Abnormal atrial myocyte Ca
objectiveThe purpose of this study was to determine whether CaMKII-dependent phosphorylation at Ser571 on Na
methodsAtrial myocyte electrophysiology, Ca
resultsAtrial myocytes from S571E but not S571A mice displayed an increase in I
conclusionThis study identified CaMKII-dependent regulation of Na
Indexed as
AnimalsAtrial FibrillationCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Cells, CulturedDisease Models, AnimalFemaleHumansMaleMiceMyocytes, CardiacSodiumCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2SodiumArrhythmiaAtrial fibrillationCalcium/calmodulin-dependent kinase IILate sodium currentType 2 ryanodine receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.