Evidence map›Paper›PMID 31622438›Full record

ArticlePloS one2019

Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort.

Daniela Rohde, Eva Gaynor, Margaret Large, Lisa Mellon, Kathleen Bennett, David J Williams, Linda Brewer, Patricia Hall, Elizabeth Callaly, Eamon Dolan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  17. Hypertension and Drug Adherence in the Elderly.Frontiers in cardiovascular medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Daniela RohdeDivision of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0001-8834-2539
Eva GaynorDepartment of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Margaret LargeClinical Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Lisa MellonDivision of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Kathleen BennettDivision of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
David J WilliamsGeriatric and Stroke Medicine, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.
Linda BrewerGeriatric and Stroke Medicine, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.
Patricia HallClinical Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Elizabeth CallalyGeriatric Medicine, Mater Misericordiae University Hospital, Dublin, Ireland.
Eamon DolanGeriatric Medicine, Connolly Hospital, Dublin, Ireland.
Anne HickeyDivision of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Royal College of Surgeons in Ireland · IEConnolly Hospital Blanchardstown · IEMater Misericordiae University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundControl of vascular risk factors is essential for secondary stroke prevention. However, adherence to secondary prevention medications is often suboptimal, and may be affected by cognitive impairment. Few studies to date have examined associations between cognitive impairment and medication adherence post-stroke, and none have considered whether adherence to secondary prevention medications might affect subsequent cognitive function. The aim of this study was to explore prospective associations between cognitive impairment and medication non-adherence post-stroke.

methodsA five-year follow-up of 108 stroke survivors from the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) prospective observational cohort study. Cognitive function was assessed using the Montreal Cognitive Assessment at 6 months, and a neuropsychological test battery at 5 years. Adherence to antihypertensive, antithrombotic and lipid-lowering medications was assessed using prescription refill data.

resultsThe prevalence of cognitive impairment at five years was 35.6%. The prevalence of non-adherence ranged from 15.1% for lipid-lowering agents to 30.2% for antithrombotics. There were no statistically significant associations between medication non-adherence in the first year post-stroke and cognitive impairment at 5 years, nor between cognitive impairment at 6 months and non-adherence at 5 years. Stroke survivors with cognitive impairment were significantly more likely to report receiving help with taking medications [OR (95% CI): 4.84 (1.17, 20.07)].

conclusionsThis is the first study to explore the potential impact of non-adherence to secondary prevention medications on cognitive impairment in stroke survivors. Findings highlight the role of family members and caregivers in assisting stroke survivors with medication administration, particularly in the context of deficits in cognitive function. Involving family members and caregivers may be a legitimate and cost-effective strategy to improve medication adherence in stroke survivors.

Indexed as

Drug MonitoringAgedAged, 80 and overAntihypertensive AgentsCaregiversCognitive DysfunctionCohort StudiesFemaleFibrinolytic AgentsFollow-Up StudiesHumansHypolipidemic AgentsMaleMiddle AgedNeuropsychological TestsPrevalenceAntihypertensive AgentsFibrinolytic AgentsHypolipidemic Agents

Identifiers

PMID31622438
PMCPMC6797135
OpenAlexW2981008404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.