SynthesisPloS one2019
Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review.
Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Efficacy of Bioceramic Cements Versus Conventional Cements in the Prognosis of Endodontic Treatments in Patients with Apical Periodontitis: A Systematic Review with Meta-Analysis.Iranian endodontic journal · 2026Review
- Periapical Lesion Healing After Retreatment and Root Canal Filling with a Bioceramic-Based Sealer: A Randomized Clinical Study with 1-Year Follow-Up.Journal of clinical medicine · 2025Article
- In Vivo Comparison of Resin-Modified and Pure Calcium-Silicate Cements for Direct Pulp Capping.Applied sciences (Basel, Switzerland) · 2025Article
- A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms.Bioengineering (Basel, Switzerland) · 2025Article
- Comparative Evaluation of Three Calcium Silicate-Based Materials for Direct Pulp Capping: AnbioRxiv : the preprint server for biology · 2025Article
- Physicochemical properties, bond strength, and antibiofilm activity of a powder-gel bioceramic endodontic sealer.Brazilian dental journal · 2025Article
- The importance of interdisciplinary collaboration in advanced therapy of odontogenic cysts: A 31 Month follow-up case report.Heliyon · 2024Article
- A Comparison of Conventional Root Canal Sealers With Ones That Use Green Synthesized Nanoparticles for Antimicrobial Activity: Protocol for a Systematic Review.JMIR research protocols · 2024Article
- Cytocompatibility and Antibiofilm Activity of Calcium Hydroxide Mixed withAntibiotics (Basel, Switzerland) · 2024Article
- Comparative Analysis of Interfacial Adaptation and Depth Penetration of Recent HiFlow versus Regular Bioceramic Sealers in Conjunction with BC Gutta-Percha Points Using Two Different Obturation Techniques-A Preliminary Report of an Ex Vivo Study.Journal of functional biomaterials · 2024Article
- A critical review of the material properties guiding the clinician's choice of root canal sealers.Clinical oral investigations · 2023Review
- Article
- The dentine-sealer interface: Modulation of antimicrobial effects by irrigation.International endodontic journal · 2022Article
- Physico-Chemical Properties of Calcium-Silicate vs. Resin Based Sealers-A Systematic Review and Meta-Analysis of Laboratory-Based Studies.Materials (Basel, Switzerland) · 2021Review
- Antimicrobial and Antibiofilm Properties of Bioceramic Materials in Endodontics.Materials (Basel, Switzerland) · 2021Review
- The Effect of Calcium-Silicate Cements on Reparative Dentinogenesis Following Direct Pulp Capping on Animal Models.Molecules (Basel, Switzerland) · 2021Review
- The Structural, Physical, and In Vitro Biological Performance of Freshly Mixed and Set Endodontic Sealers.European endodontic journal · 2021Article
- Impact of Warm Vertical Compaction on the Sealing Ability of Calcium Silicate-Based Sealers: A Confocal Microscopic Evaluation.Materials (Basel, Switzerland) · 2021Article
- Genotoxicity of root canal sealers: a literature review.Clinical oral investigations · 2020Review
- Efficacy of Bioceramic and Calcium Hydroxide-Based Root Canal Sealers against Pathogenic Endodontic Biofilms: AnContemporary clinical dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a new generation of bioceramic root canal sealers has been introduced onto the market. Many in vitro studies have investigated the antimicrobial properties of these sealers, but their comparative efficacy in antimicrobial activity is still unknown. METHODOLOGY: Three electronic databases were searched: MEDLINE and Embase via the OvidSP platform, and Web of Science, up to June 25, 2019. Studies were included irrespective of study design, type of publication and language. Reporting quality was assessed by two authors independently. Meta-analysis was not performed due to studies being highly heterogeneous.
resultsWe included 37 studies that analysed the antimicrobial effects of bioceramic sealers. Most of them used a planktonic cell model, with the exception of nine studies which used biofilms. It was not possible to make direct comparison of results from studies and to give a clear conclusion about the comparative antimicrobial activity of these materials because the studies used heterogeneous sources and ages of microorganisms, setting and contact times of sealers, and antimicrobial tests. Furthermore, some materials showed completely different results when tested with different methods.
conclusionsIn conclusion, multiple in vitro studies have shown that bioceramic sealers may have various degrees of antimicrobial activity. However, it is still impossible to make conclusions about their comparative efficacy and to recommend the use of one over another in clinical practice because the studies available were conducted in different ways, which makes meta-analysis futile. A uniform methodological approach, consistent definitions and studies on humans are urgently needed in this field of research so that recommendations for practice can be made.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.