SynthesisPloS one2019
The impact of leishmaniasis on mental health and psychosocial well-being: A systematic review.
Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 6 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- The Efficacy of Topical Paromomycin-Gentamicin versus Topical Paromomycin Alone in The Treatment of Cutaneous Leishmaniasis: A meta-analysis of randomized controlled trials.Sultan Qaboos University medical journal · 2025Pooled it
- The psychosocial impacts of skin-neglected tropical diseases (SNTDs) as perceived by the affected persons: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Stigma associated with cutaneous and mucocutaneous leishmaniasis: A systematic review.PLoS neglected tropical diseases · 2023Pooled it
- Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review.Global health research and policy · 2022Pooled it
- Impact of parasitic infection on mental health and illness in humans in Africa: a systematic review.Parasitology · 2022Pooled it
- Mobile Health Strategies to Tackle Skin Neglected Tropical Diseases With Recommendations From Innovative Experiences: Systematic Review.JMIR mHealth and uHealth · 2020Pooled it
- The Cutaneous leishmaniasis impact questionnaire: Translation, cross-cultural adaptation and validation in adults with Cutaneous leishmaniasis in Ethiopia.PLoS neglected tropical diseases · 2026Article
- "It left me burnt": Traditional treatment and stigma experiences of cutaneous leishmaniasis in Kalu district, Ethiopia.PLoS neglected tropical diseases · 2026Article
- Translation, cross-cultural adaptation and validation of an Afan Oromo version of the Dermatology Life Quality Index in individuals with cutaneous leishmaniasis in Ethiopia.Skin health and disease · 2026Article
- Leishmaniasis in Morocco: Epidemiology, Transmission Dynamics, and the Potential of Artificial Intelligence for Disease Management.Journal of parasitology research · 2026Review
- Leishmaniasis.Nature reviews. Disease primers · 2025Review
- Infections and cognitive function, depression, and frailty: a cross-sectional study in the longitudinal aging study in India (LASI).BMC public health · 2025Article
- Readiness Assessment of Healthcare Professionals to Integrate Mental Health Services into Primary Healthcare of Persons with Skin-Neglected Tropical Diseases in Ghana: A Structural Equation Modeling.International journal of environmental research and public health · 2025Article
- Quality of Life, Disability, and Fungal Neglected Tropical Diseases.Current fungal infection reports · 2025Article
- Synthesis and in vitro antitrypanosomatid activity of novel 5-nitroindole-rhodanine conjugates.Future medicinal chemistry · 2025Article
- Effects of cutaneous leishmaniasis on health-related quality of life: A longitudinal approach.PloS one · 2025Observational
- Unveiling the hidden burden: Exploring the psychosocial impact of cutaneous leishmaniasis lesions and scars in southern Ethiopia.PloS one · 2025Article
- Health-related quality of life in Brazilian patients with cutaneous leishmaniasis using EQ-5D.PloS one · 2025Article
- Improving reproducibility and translational potential of mouse models: lessons from studying leishmaniasis.Frontiers in immunology · 2025Review
- Quality of life in cutaneous leishmaniasis patients in Khyber Pakhtunkhwa, Pakistan.Pakistan journal of medical sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundLeishmaniasis is a neglected tropical parasitic disease endemic in South Asia, East Africa, Latin America and the Middle East. It is associated with low socioeconomic status (SES) and responsible for considerable mortality and morbidity. Reports suggest that patients with leishmaniasis may have a higher risk of mental illness (MI), psychosocial morbidity (PM) and reduced quality of life (QoL), but this is not well characterised. The aim of this study was to conduct a systematic review to assess the reported impact of leishmaniasis on mental health and psychosocial wellbeing.
methodsA systematic review of the literature was carried out. Pre-specified criteria were applied to identify publications including observational quantitative studies or systematic reviews. Two reviewers screened all of the titles, abstracts and full-studies and a third reviewer was consulted for disagreements. Data was extracted from papers meeting the criteria and quality appraisal of the methods was performed using the Newcastle-Ottawa Scale or the Risk of Bias in Systematic Review tool.
resultsA total of 14 studies were identified from 12,517 records. Nine cross-sectional, three case-control, one cohort study and one systematic review were included. Eleven assessed MI outcomes and were measured with tools specifically designed for this; nine measured PM and 12 measured QoL using validated measurement tools. Quality appraisal of the studies showed that six were of good quality. Cutaneous leishmaniasis and post kala-azar dermal leishmaniasis showed evidence of associated MI and PM including depression, anxiety and stigma, while all forms of disease showed decreased QoL. The findings were used to inform a proposed model and conceptual framework to show the possible links between leishmaniasis and mental health outcomes.
conclusionThere is evidence that leishmaniasis has an impact on MI, PM or QoL of patients and their families and this occurs in all the main subtypes of the disease. There are however large gaps in the evidence. Further research is required to understand the full extent of this problem and its mechanistic basis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.