ArticlePLoS computational biology2019
Action potential propagation and synchronisation in myelinated axons.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Zebrafish oligodendrocyte lineage cells use the postsynaptic protein Gephyrin to myelinate GABAergic axons and limit myelin sheath growth.Nature communications · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease.Frontiers in neuroscience · 2026Review
- Regular afferent activity and structural homogeneity gate ephaptic synchronization in the dorsal column.Frontiers in human neuroscience · 2026Article
- Axon collateralization and focal myelin dystrophy alter action potential propagation in multicompartment pyramidal neuron models.PLoS computational biology · 2025Article
- Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling.ACS nano · 2025Article
- Saltatory axonal conduction in the avian retina.The Journal of physiology · 2025Article
- Short-range human cortico-cortical white matter fibers have thinner axons and are less myelinated compared to long-range fibers despite a similar g-ratio.PLoS biology · 2025Article
- Spatial Heterogeneity in Myelin Sheathing Impacts Signaling Reliability and Susceptibility to Injury.eNeuro · 2025Article
- White-Matter Structural Connectivity and Alzheimer's Disease: A Mendelian Randomization Study.Brain and behavior · 2025Article
- The wave nature of the action potential.Frontiers in cellular neuroscience · 2025Article
- Oligodendrocytes use postsynaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes.bioRxiv : the preprint server for biology · 2024Article
- Article
- Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Evolutionary origins of synchronization for integrating information in neurons.Frontiers in cellular neuroscience · 2024Review
- Pathophysiology in cortico-amygdala circuits and excessive aversion processing: the role of oligodendrocytes and myelination.Brain communications · 2024Review
- From Black Holes Entropy to Consciousness: The Dimensions of the Brain Connectome.Entropy (Basel, Switzerland) · 2023Article
- Quantitative MRI reveals widespread, network-specific myelination change during generalized epilepsy progression.NeuroImage · 2023Article
- Myelin dystrophy in the aging prefrontal cortex leads to impaired signal transmission and working memory decline: a multiscale computational study.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the advent of advanced MRI techniques it has become possible to study axonal white matter non-invasively and in great detail. Measuring the various parameters of the long-range connections of the brain opens up the possibility to build and refine detailed models of large-scale neuronal activity. One particular challenge is to find a mathematical description of action potential propagation that is sufficiently simple, yet still biologically plausible to model signal transmission across entire axonal fibre bundles. We develop a mathematical framework in which we replace the Hodgkin-Huxley dynamics by a spike-diffuse-spike model with passive sub-threshold dynamics and explicit, threshold-activated ion channel currents. This allows us to study in detail the influence of the various model parameters on the action potential velocity and on the entrainment of action potentials between ephaptically coupled fibres without having to recur to numerical simulations. Specifically, we recover known results regarding the influence of axon diameter, node of Ranvier length and internode length on the velocity of action potentials. Additionally, we find that the velocity depends more strongly on the thickness of the myelin sheath than was suggested by previous theoretical studies. We further explain the slowing down and synchronisation of action potentials in ephaptically coupled fibres by their dynamic interaction. In summary, this study presents a solution to incorporate detailed axonal parameters into a whole-brain modelling framework.
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