ArticlePLoS biology2019
Ratiometric GPCR signaling enables directional sensing in yeast.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Regulation of the Cell Wall Integrity pathway at the contact site between mating partners in yeast.The Journal of cell biology · 2026Article
- Ratiometric signaling produces robust temporal integration for accurate cellular gradient sensing.bioRxiv : the preprint server for biology · 2026Article
- Phenylacetate Hydroxylase SsPhacA Modulates p-Coumaric Acid Accumulation to Regulate the Mating/Filamentation of Sporisorium scitamineum.Molecular plant pathology · 2025Article
- Role of Gα-MAPK interaction in mating ofMolecular biology of the cell · 2025Article
- Individual yeast cells signal at different levels but each with good precision.Royal Society open science · 2025Article
- Kinetic Monte Carlo methods for three-dimensional diffusive capture problems in exterior domains.Royal Society open science · 2025Article
- Design patterns of biological cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Particle-based simulations reveal two positive feedback loops allow relocation and stabilization of the polarity site during yeast mating.PLoS computational biology · 2023Article
- Single-cell directional sensing from just a few receptor binding events.Biophysical journal · 2023Article
- Short-time diffusive fluxes over membrane receptors yields the direction of a signalling source.Royal Society open science · 2023Article
- Mechanism of commitment to a mating partner inMolecular biology of the cell · 2022Article
- Comparison of Experimental Approaches Used to Determine the Structure and Function of the Class D G Protein-Coupled Yeast α-Factor Receptor.Biomolecules · 2022Review
- Orientation of Cell Polarity by Chemical Gradients.Annual review of biophysics · 2022Review
- Pheromone Guidance of Polarity Site Movement in Yeast.Biomolecules · 2022Article
- A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement.PLoS computational biology · 2021Article
- Chemotactic movement of a polarity site enables yeast cells to find their mates.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Exploratory polarization facilitates mating partner selection inMolecular biology of the cell · 2021Article
- Mechanisms that ensure monogamous mating inMolecular biology of the cell · 2021Article
- Molecular switch architecture determines response properties of signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mechanistic insights into actin-driven polarity site movement in yeast.Molecular biology of the cell · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Accurate detection of extracellular chemical gradients is essential for many cellular behaviors. Gradient sensing is challenging for small cells, which can experience little difference in ligand concentrations on the up-gradient and down-gradient sides of the cell. Nevertheless, the tiny cells of the yeast Saccharomyces cerevisiae reliably decode gradients of extracellular pheromones to find their mates. By imaging the behavior of polarity factors and pheromone receptors, we quantified the accuracy of initial polarization during mating encounters. We found that cells bias the orientation of initial polarity up-gradient, even though they have unevenly distributed receptors. Uneven receptor density means that the gradient of ligand-bound receptors does not accurately reflect the external pheromone gradient. Nevertheless, yeast cells appear to avoid being misled by responding to the fraction of occupied receptors rather than simply the concentration of ligand-bound receptors. Such ratiometric sensing also serves to amplify the gradient of active G protein. However, this process is quite error-prone, and initial errors are corrected during a subsequent indecisive phase in which polarity clusters exhibit erratic mobile behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.