ArticleMolecular plant pathology2019
Host-induced gene silencing of BcTOR in Botrytis cinerea enhances plant resistance to grey mould.
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 59 citations in OpenAlex.
- LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens.Plant biotechnology journal · 2026Article
- Engineering Plant-Associated Microorganisms for Bioremediation and Sustainable Agriculture.Microorganisms · 2026Review
- Functional analysis of target of rapamycin in regulating mycelial growth and development in Penicillium italicum.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- ROS-responsive nanoliposomes loaded with anti-oomycetes medium-chain fatty acids for shuttling delivery in plant disease control.Journal of nanobiotechnology · 2026Article
- Plant RNA interference from antiviral silencing to multiplex trait engineering for climate-resilient crops.Frontiers in plant science · 2026Review
- Mechanisms of regulated cell death during plant infection by the rice blast fungus Magnaporthe oryzae.Cell death and differentiation · 2025Review
- The TOR Signaling Pathway Governs Fungal Development, Virulence and Ustiloxin Biosynthesis inJournal of fungi (Basel, Switzerland) · 2025Article
- Review
- The TOR signalling pathway in fungal phytopathogens: A target for plant disease control.Molecular plant pathology · 2024Review
- RNA interference: a promising biotechnological approach to combat plant pathogens, mechanism and future prospects.World journal of microbiology & biotechnology · 2024Review
- Mycologists and Virologists Align: ProposingViruses · 2024Review
- Challenges and Opportunities Arising from Host-International journal of molecular sciences · 2024Review
- Why Do We Need Alternative Methods for Fungal Disease Management in Plants?Plants (Basel, Switzerland) · 2023Review
- Spray-induced gene silencing to identify powdery mildew gene targets and processes for powdery mildew control.Molecular plant pathology · 2023Article
- A New Insight into 6-Pentyl-2H-pyran-2-one againstJournal of fungi (Basel, Switzerland) · 2023Article
- Constitutive activation of TORC1 signalling attenuates virulence in the cross-kingdom fungal pathogen Fusarium oxysporum.Molecular plant pathology · 2023Article
- Engineering crop Phytophthora resistance by targeting pathogen-derived PI3P for enhanced catabolism.Plant communications · 2023Article
- Molecular characterization of cross-kingdom RNA interference inFrontiers in plant science · 2023Article
- Genome-Wide Identification and Analysis of FKBP Gene Family in Wheat (International journal of molecular sciences · 2022Article
- TOR inhibition primes immunity and pathogen resistance in tomato in a salicylic acid-dependent manner.Molecular plant pathology · 2022Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Botrytis cinerea is the causal agent of grey mould for more than 200 plant species, including economically important vegetables, fruits and crops, which leads to economic losses worldwide. Target of rapamycin (TOR) acts a master regulator to control cell growth and proliferation by integrating nutrient, energy and growth factors in eukaryotic species, but little is known about whether TOR can function as a practicable target in the control of plant fungal pathogens. Here, we characterize TOR signalling of B. cinerea in the regulation of growth and pathogenicity as well as its potential value in genetic engineering for crop protection by bioinformatics analysis, pharmacological assays, biochemistry and genetics approaches. The results show that conserved TOR signalling occurs, and a functional FK506-binding protein 12 kD (FKBP12) mediates the interaction between rapamycin and B. cinerea TOR (BcTOR). RNA sequencing (RNA-Seq) analysis revealed that BcTOR displayed conserved functions, particularly in controlling growth and metabolism. Furthermore, pathogenicity assay showed that BcTOR inhibition efficiently reduces the infection of B. cinerea in plant leaves of Arabidopsis and potato or tomato fruits. Additionally, transgenic plants expressing double-stranded RNA of BcTOR through the host-induced gene silencing method could produce abundant small RNAs targeting BcTOR, and significantly block the occurrence of grey mould in potato and tomato. Taken together, our results suggest that BcTOR is an efficient target for genetic engineering in control of grey mould, and also a potential and promising target applied in the biocontrol of plant fungal pathogens.
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