Evidence map›Paper›PMID 31621989›Full record

ArticleHippocampus2020

Functional responses of the hippocampus to hyperexcitability depend on directed, neuron-specific KCNQ2 K

Chase M Carver, Shayne D Hastings, Mileah E Cook, Mark S Shapiro

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hippocampus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pharmacological Manipulation of KFrontiers in physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chase M CarverDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, Texas.ORCID 0000-0003-4002-2418
Shayne D HastingsDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, Texas.ORCID 0000-0002-6303-0181
Mileah E CookDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, Texas.
Mark S ShapiroDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, Texas.ORCID 0000-0002-9630-0600
The University of Texas Health Science Center at San Antonio · US

Funding

PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
Modulation of Neuronal Ion Channels by 2nd MessengersR01NS043394 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2002 to 2014
$4.5M
Targeting specific interactions between A-kinase Anchoring Proteins (AKAPs) and ion channels with cell-permeant peptides as a novel mode of therapeutic intervention against pain disordersR01NS094461 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2015 to 2019
$2.0M
Mechanism and functional role of AKAP79/150 in M current control and excitabilityR01NS065138 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2009 to 2010
$788k
CSR NIH HHS T32 HL007446NHLBI NIH HHS T32 HL007446NINDS NIH HHS R01 NS043394NINDS NIH HHS R01 NS065138NINDS NIH HHS R01 NS094461
6 · The paper itself

Abstract

M-type (KCNQ2/3) K

Indexed as

AnimalsDose-Response Relationship, DrugFemaleHippocampusKCNQ2 Potassium ChannelMaleMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeuronal PlasticityNeuronsOrgan Culture TechniquesPilocarpineKCNQ2 Potassium ChannelKcnq2 protein, mouseNerve Tissue ProteinsPilocarpineepileptogenesishippocampushyperexcitabilityKCNQ channelsplasticity

Identifiers

PMID31621989
PMCPMC8162063
OpenAlexW2980667808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.