Evidence map›Paper›PMID 31621602›Full record

Observational studyParkinsonism & related disorders2019

Long-term trends in myocardial sympathetic innervation and function in synucleinopathies.

Guillaume Lamotte, Courtney Holmes, Tianxia Wu, David S Goldstein

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Parkinsonism & related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Value of multi-parameterEJNMMI research · 2025
    Article
  4. Orthostatic hypotension in Parkinson's disease: therapeutic considerations.Therapeutic advances in neurological disorders · 2025
    Review
  5. Article
  6. Review
  7. A pathophysiological biomarker combination separates Lewy body from non-Lewy body neurogenic orthostatic hypotension ​.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Observational
  8. CardiacClinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Review
  9. IsClinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
  10. Article
  11. What new can we learn from cardiac sympathetic neuroimaging in synucleinopathies?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. CardiacMovement disorders clinical practice · 2021
    Article
  16. Review
  17. Appropriate assessment method ofJournal of neurology · 2020
    Article
  18. The catecholaldehyde hypothesis: where MAO fits in.Journal of neural transmission (Vienna, Austria : 1996) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guillaume LamotteClinical Neurosciences Program (CNP), Division of Intramural Research (CNP), National Institute of Neurological Disorders and Stroke (NINDS), 9000 Rockville Pike 10/8C260, Bethesda, MD, 20892, USA; Clinical Neurocardiology Section, CNP/DIR/NINDS/NIH, 9000 Rockville Pike 10/8C260, Bethesda, MD, 20892, USA. Electronic address: guillaume.lamotte@nih.gov/.
Courtney HolmesClinical Neurocardiology Section, CNP/DIR/NINDS/NIH, 9000 Rockville Pike 10/8C260, Bethesda, MD, 20892, USA. Electronic address: holmesc@ninds.nih.gov.
Tianxia WuClinical Trials Unit, NINDS, 9000 Rockville Pike 10/2A23B, Bethesda, MD, 20892, USA. Electronic address: wuti@mail.nih.gov.
David S GoldsteinClinical Neurocardiology Section, CNP/DIR/NINDS/NIH, 9000 Rockville Pike 10/8C260, Bethesda, MD, 20892, USA. Electronic address: goldsteind@ninds.nih.gov.
National Institutes of Health · US

Funding

Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

introductionParkinson disease (PD), pure autonomic failure (PAF), and multiple system atrophy (MSA) are characterized by intra-cerebral deposition of the protein alpha-synuclein and are termed synucleinopathies. Lewy body synucleinopathies involve decreased cardiac sympathetic innervation and functional abnormalities in residual noradrenergic terminals. This observational, retrospective, cohort study describes long-term trends in indices of cardiac sympathetic innervation and function in synucleinopathies.

methodsPatients with PD (N = 31), PAF (N = 9), or MSA (N = 9) underwent repeated

resultsUpon initial evaluation the groups with PD and orthostatic hypotension (OH), PAF, or PD and no OH had low mean 8' Radioactivity compared to HVs (p < 0.0001, p = 0.0002, p = 0.006) and had elevated k

conclusionsNeuroimaging evidence of decreased vesicular uptake in cardiac sympathetic nerves is present upon initial evaluation of patients with Lewy body synucleinopathies and may provide a biomarker of catecholaminergic dysfunction early in the disease process.

Indexed as

AdultAgedCase-Control StudiesDisease ProgressionDopamineFemaleFluorine RadioisotopesHeartHumansHypotension, OrthostaticLewy Body DiseaseMaleMiddle AgedMultiple System AtrophyMyocardiumParkinson DiseaseDopamineFluorine RadioisotopesFluorodopamineMultiple system atrophyParkinson diseasePure autonomic failureSympathetic nervous system

Identifiers

PMID31621602
PMCPMC7031858
OpenAlexW2974791732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.