ArticleJournal of endocrinological investigation2020
Cognition and cerebrovascular function in primary hyperparathyroidism before and after parathyroidectomy.
Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Heterogeneous Phenotypes of Primary Hyperparathyroidism in Romania: Characterization of a Large Cohort.Journal of clinical medicine · 2026Article
- Osteoporosis and Normocalcemic Primary Hyperparathyroidism (Conservatively or Surgically Managed).Journal of clinical medicine · 2024Review
- Secular trends in the incidence and treatment patterns of primary hyperparathyroidism in Korea: a nationwide cohort study.JBMR plus · 2024Article
- Machine learning-based prediction models for parathyroid carcinoma using pre-surgery cognitive function and clinical features.Scientific reports · 2023Article
- Effects of successful parathyroidectomy on neuropsychological and cognitive status in patients with asymptomatic primary hyperparathyroidism.Endocrine · 2023Article
- Secondary Hyperparathyroidism and Cognitive Decline.Current transplantation reports · 2023Article
- Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System.Journal of personalized medicine · 2023Review
- Cognitive deficits in primary hyperparathyroidism - what we know and what we do not know: A narrative review.Reviews in endocrine & metabolic disorders · 2022Review
- The impact of age on quality of life and frailty outcomes after parathyroidectomy in patients with primary hyperparathyroidism.Journal of endocrinological investigation · 2022Article
- Successful parathyroidectomy improves cognition in patients with primary hyperparathyroidism: A prospective study in a tertiary medical center and comprehensive review of the literature.Frontiers in endocrinology · 2022Review
- Parathyroidectomy slows renal function decline in patients with primary hyperparathyroidism.Journal of endocrinological investigation · 2021Article
- The Associations of Serum Osteocalcin and Cortisol Levels With the Psychological Performance in Primary Hyperparathyroidism Patients.Frontiers in endocrinology · 2021Article
- Review
- Functional magnetic resonance imaging in primary hyperparathyroidism.European journal of endocrinology · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
purposeThere are cognitive changes in primary hyperparathyroidism (PHPT) that improve with parathyroidectomy, but the mechanism of cognitive dysfunction has not been delineated. We assessed if cerebrovascular function is impaired in PHPT, improves post-parathyroidectomy and is associated with PTH level and cognitive dysfunction.
methodsThis is an observational study of 43 patients with mild hypercalcemic or normocalcemic PHPT or goiter. At baseline, cerebrovascular function (dynamic cerebral autoregulation and vasomotor reactivity) by transcranial Doppler and neuropsychological function were compared between all three groups. A subset underwent parathyroidectomy or thyroidectomy, and was compared 6 months post-operatively.
resultsMean cerebrovascular and neuropsychological function was normal and no worse in PHPT compared to controls preoperatively. Higher PTH was associated with worse intracerebral autoregulation (r = - 0.43, p = 0.02) and worse cognitive performance on some tests. Post-parathyroidectomy, mood improved significantly, but changes did not differ compared to those having thyroidectomy (p = 0.84). There was no consistent improvement in cognition or change in vascular function in either surgical group.
conclusionsAlthough higher PTH was associated with worse intracerebral autoregulation, cerebrovascular function, cognition and mood were normal in mild PHPT. PTX did not improve vascular or cognitive function. The observed improvement in mood cannot be clearly attributed to PTX. Notwithstanding the small sample size, the results do not support changing current criteria for parathyroidectomy to include cognitive complaints. However, the associations between PTH, cognition and cerebral autoregulation merit future studies in those with more severe hyperparathyroidism.
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