ArticleNucleic acids research2020
PADS Arsenal: a database of prokaryotic defense systems related genes.
Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Biology of host-dependent restriction-modification in prokaryotes.EcoSal Plus · 2025Review
- In silico approaches for discovering microbial antiviral defense systems.Briefings in bioinformatics · 2025Review
- Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs.Cell research · 2024Article
- Genomic and transcriptomic insights into complex virus-prokaryote interactions in marine biofilms.The ISME journal · 2023Article
- Insertion sequence transposition inactivates CRISPR-Cas immunity.Nature communications · 2023Article
- Genomic insights into the adaptation ofFrontiers in microbiology · 2023Article
- Systematic and quantitative view of the antiviral arsenal of prokaryotes.Nature communications · 2022Article
- Precipitous Increase of Bacterial CRISPR-Cas Abundance at Around 45°C.Frontiers in microbiology · 2022Article
- An Interplay between Viruses and Bacteria Associated with the White Sea Sponges Revealed by Metagenomics.Life (Basel, Switzerland) · 2021Article
- Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types.Nucleic acids research · 2021Article
- Adaptive Laboratory Evolution as a Means To Generate Lactococcus lactis Strains with Improved Thermotolerance and Ability To Autolyze.Applied and environmental microbiology · 2021Article
- Co-Occurrence ofAntibiotics (Basel, Switzerland) · 2021Article
- Arms race in a cell: genomic, transcriptomic, and proteomic insights into intracellular phage-bacteria interplay in deep-sea snail holobionts.Microbiome · 2021Article
- Article
- Phages in the Gut Ecosystem.Frontiers in cellular and infection microbiology · 2021Review
- The Hyperthermophilic Restriction-Modification Systems ofFrontiers in microbiology · 2021Article
- Genomic Analysis of Molecular Bacterial Mechanisms of Resistance to Phage Infection.Frontiers in microbiology · 2021Article
- Functional genomics reveals the toxin-antitoxin repertoire and AbiE activity inMicrobial genomics · 2020Article
- The 27th annual Nucleic Acids Research database issue and molecular biology database collection.Nucleic acids research · 2020Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defense systems are vital weapons for prokaryotes to resist heterologous DNA and survive from the constant invasion of viruses, and they are widely used in biochemistry investigation and antimicrobial drug research. So far, numerous types of defense systems have been discovered, but there is no comprehensive defense systems database to organize prokaryotic defense gene datasets. To fill this gap, we unveil the prokaryotic antiviral defense system (PADS) Arsenal (https://bigd.big.ac.cn/padsarsenal), a public database dedicated to gathering, storing, analyzing and visualizing prokaryotic defense gene datasets. The initial version of PADS Arsenal integrates 18 distinctive categories of defense system with the annotation of 6 600 264 genes retrieved from 63,701 genomes across 33 390 species of archaea and bacteria. PADS Arsenal provides various ways to retrieve defense systems related genes information and visualize them with multifarious function modes. Moreover, an online analysis pipeline is integrated into PADS Arsenal to facilitate annotation and evolutionary analysis of defense genes. PADS Arsenal can also visualize the dynamic variation information of defense genes from pan-genome analysis. Overall, PADS Arsenal is a state-of-the-art open comprehensive resource to accelerate the research of prokaryotic defense systems.
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