ArticleNeurophotonics2019
High-density speckle contrast optical tomography of cerebral blood flow response to functional stimuli in the rodent brain.
Article in Neurophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Mapping human cerebral blood flow with high-density, multi-channel speckle contrast optical spectroscopy.Communications biology · 2025Article
- Optimized laser speckle-based imaging system and methods for deep tissue cerebral blood flow imaging in small rodents.Neurophotonics · 2025Article
- Programmable scanning diffuse speckle contrast imaging of cerebral blood flow.Neurophotonics · 2025Article
- Article
- Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements.Biomedical optics express · 2024Article
- Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography.Journal of biomedical optics · 2023Article
- Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents.Neurophotonics · 2023Article
- SpeckleCam: high-resolution computational speckle contrast tomography for deep blood flow imaging.Biomedical optics express · 2023Article
- Anatomical Modeling and Optimization of Speckle Contrast Optical Tomography.bioRxiv : the preprint server for biology · 2023Article
- Synthetic exposure with a CMOS camera for multiple exposure speckle imaging of blood flow.Scientific reports · 2022Article
- High-resolution three-dimensional blood flow tomography in the subdiffuse regime using laser speckle contrast imaging.Journal of biomedical optics · 2022Article
- Extraction of tissue optical property and blood flow from speckle contrast diffuse correlation tomography (scDCT) measurements.Biomedical optics express · 2021Article
- Dissecting the microvascular contributions to diffuse correlation spectroscopy measurements of cerebral hemodynamics using optical coherence tomography angiography.Neurophotonics · 2021Article
- Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets.Journal of biophotonics · 2021Article
- Time resolved speckle contrast optical spectroscopy at quasi-null source-detector separation for non-invasive measurement of microvascular blood flow.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Noninvasive, three-dimensional, and longitudinal imaging of cerebral blood flow (CBF) in small animal models and ultimately in humans has implications for fundamental research and clinical applications. It enables the study of phenomena such as brain development and learning and the effects of pathologies, with a clear vision for translation to humans. Speckle contrast optical tomography (SCOT) is an emerging optical method that aims to achieve this goal by directly measuring three-dimensional blood flow maps in deep tissue with a relatively inexpensive and simple system. High-density SCOT is developed to follow CBF changes in response to somatosensory cortex stimulation. Measurements are carried out through the intact skull on the rat brain. SCOT is able to follow individual trials in each brain hemisphere, where signal averaging resulted in comparable, cortical images to those of functional magnetic resonance images in spatial extent, location, and depth. Sham stimuli are utilized to demonstrate that the observed response is indeed due to local changes in the brain induced by forepaw stimulation. In developing and demonstrating the method, algorithms and analysis methods are developed. The results pave the way for longitudinal, nondestructive imaging in preclinical rodent models that can readily be translated to the human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.