Evidence map›Paper›PMID 31620544›Full record

ArticleNeurophotonics2019

Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study.

Mohit Ganguly, Jeremy B Ford, Junqi Zhuo, Matthew T McPheeters, Michael W Jenkins, Hillel J Chiel, E Duco Jansen

Open access · goldAbstract read
In one paragraph

Article in Neurophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Article
  9. Review
  10. Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.Neuromodulation : journal of the International Neuromodulation Society · 2023
    Article
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  18. Use of an invertebrate animal model (Frontiers in neuroscience · 2022
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mohit GangulyVanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee, United States.ORCID https://orcid.org/0000-0001-5524-5505
Jeremy B FordVanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee, United States.ORCID https://orcid.org/0000-0003-3654-3325
Junqi ZhuoCase Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio, United States.ORCID https://orcid.org/0000-0003-4260-768X
Matthew T McPheetersCase Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio, United States.ORCID https://orcid.org/0000-0001-9617-3157
Michael W JenkinsCase Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio, United States.ORCID https://orcid.org/0000-0002-8908-5383
Hillel J ChielCase Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio, United States.
E Duco JansenVanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee, United States.ORCID https://orcid.org/0000-0002-1778-6180
Case Western Reserve University · USVanderbilt University · US

Funding

Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart DefectsR01HL126747 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JENKINS, MICHAEL W. · 2015 to 2025
$6.4M
Infrared Neuromodulation Reveals a New Understanding of Ganglion OrganizationOT2OD025307 · OD · CASE WESTERN RESERVE UNIVERSITY · PI JENKINS, MICHAEL W. · 2017 to 2020
$5.4M
NHLBI NIH HHS R01 HL126747NIH HHS OT2 OD025307
6 · The paper itself

Abstract

Thermal block of unmyelinated axons may serve as a modality for control, suggesting a means for providing therapies for pain. Computational modeling predicted that potassium channels are necessary for mediating thermal block of propagating compound action potentials (CAPs) with infrared (IR) light. Our study tests that hypothesis. Results suggest that potassium channel blockers disrupt the ability of IR to block propagating CAPs in

Indexed as

infrared inhibitionpotassium channelssodium channelstetraethylammonium chloridetetrodotoxin

Identifiers

PMID31620544
PMCPMC6792434
OpenAlexW2980849965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.