Evidence map›Paper›PMID 31620439›Full record

ArticleFrontiers in cell and developmental biology2019

Aggregated and Hyperstable Damage-Associated Molecular Patterns Are Released During ER Stress to Modulate Immune Function.

Alexander Andersohn, M Iveth Garcia, Ying Fan, Max C Thompson, Askar M Akimzhanov, Abdikarim Abdullahi, Marc G Jeschke, Darren Boehning

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. FAS(APO), DAMP, and AKT Phosphoproteins Expression Predict the Development of Nosocomial Infection After Pediatric Burn Injury.Journal of burn care & research : official publication of the American Burn Association · 2024
    Article
  2. Article
  3. Article
  4. Metformin-induced activation of CaJournal of translational autoimmunity · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alexander AndersohnDepartment of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX, United States.
M Iveth GarciaDepartment of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX, United States.
Ying FanDepartment of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX, United States.
Max C ThompsonDepartment of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX, United States.
Askar M AkimzhanovDepartment of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX, United States.
Abdikarim AbdullahiRoss Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Marc G JeschkeRoss Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Darren BoehningDepartment of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX, United States.
The University of Texas Health Science Center at Houston · USHealth Sciences Centre · CASunnybrook Health Science Centre · CA

Funding

Mechanisms of Apoptotic Calcium SignalingR01GM081685 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BOEHNING, DARREN F · 2007 to 2020
$4.3M
Dynamic Protein Palmitoylation in Cell SignalingR01GM115446 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI AKIMZHANOV, ASKAR · 2016 to 2020
$2.0M
Hepatic ER stress contributes to morbidity and mortality after burn injury.R01GM087285 · NIGMS · SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR · PI BOEHNING, DARREN F, JESCHKE, MARC GERHARD · 2010 to 2018
$1.9M
NIGMS NIH HHS R01 GM081685NIGMS NIH HHS R01 GM087285NIGMS NIH HHS R01 GM115446
6 · The paper itself

Abstract

Chronic ER stress occurs when protein misfolding in the Endoplasmic reticulum (ER) lumen remains unresolved despite activation of the unfolded protein response. We have shown that traumatic injury such as a severe burn leads to chronic ER stress

Indexed as

burncytokinedamage-associated molecular patternDAMPdendritic cellER stressinflammationtrauma

Identifiers

PMID31620439
PMCPMC6759876
OpenAlexW2971464833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.