Evidence map›Paper›PMID 31620436›Full record

ArticleFrontiers in cell and developmental biology2019

Collagen Dynamics During the Process of Osteocyte Embedding and Mineralization.

Lora A Shiflett, LeAnn M Tiede-Lewis, Yixia Xie, Yongbo Lu, Eleanor C Ray, Sarah L Dallas

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 52 citations in OpenAlex.

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  11. Live Cell Imaging of Bone Cell and Organ Cultures.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lora A ShiflettDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, United States.
LeAnn M Tiede-LewisDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, United States.
Yixia XieDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, United States.
Yongbo LuDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, United States.
Eleanor C RayDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, United States.
Sarah L DallasDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, United States.
University of Missouri–Kansas City · USTexas A&M University · US

Funding

Transgenic and Mechanical Loading CoreP01AG039355 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI BONEWALD, LYNDA F · 2012 to 2024
$19.3M
DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINSR01AR051517 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DALLAS, SARAH L · 2004 to 2014
$2.9M
Leica TCS Sp8 MP Multiphoton MicroscopeS10OD021665 · OD · UNIVERSITY OF MISSOURI KANSAS CITY · PI DALLAS, SARAH L · 2016 to 2016
$600k
Zeiss LSM 710 Confocal Microscopy System for Imaging of Mineralized TissuesS10RR027668 · NCRR · UNIVERSITY OF MISSOURI KANSAS CITY · PI DALLAS, SARAH L · 2011 to 2011
$446k
Optimizing Normal Collagen Replacement in Osteogenesis ImperfectaR21AR062346 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DALLAS, SARAH L · 2012 to 2013
$375k
Dynamics of Assembly of Bone Matrix ProteinsR56AR051517 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DALLAS, SARAH L · 2009 to 2009
$363k
Osteocytes as Dynamic CellsR21AR054449 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DALLAS, SARAH L · 2007 to 2008
$340k
NCRR NIH HHS S10 RR027668NIAMS NIH HHS R01 AR051517NIAMS NIH HHS R21 AR054449NIAMS NIH HHS R21 AR062346NIAMS NIH HHS R56 AR051517NIA NIH HHS P01 AG039355NIH HHS S10 OD021665
6 · The paper itself

Abstract

Bone formation, remodeling and repair are dynamic processes, involving cell migration, ECM assembly, osteocyte embedding, and bone resorption. Using live-cell imaging, we previously showed that osteoblast assembly of the ECM proteins fibronectin and collagen is highly dynamic and is integrated with cell motility. Additionally, osteoblast-to-osteocyte transition involved arrest of cell motility, followed by dendrite extension and retraction that may regulate positioning of embedding osteocytes. To further understand how osteocytes differentiate and embed in collagen, mice were generated that co-expressed GFP

Indexed as

bone mineralizationcollagenembeddingextracellular matrixlive cell imagingmotilityosteocytes

Identifiers

PMID31620436
PMCPMC6759523
OpenAlexW2968307331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.