Evidence map›Paper›PMID 31620432›Full record

ArticleFrontiers in bioengineering and biotechnology2019

Bromination of L-tryptophan in a Fermentative Process With

Kareen H Veldmann, Steffen Dachwitz, Joe Max Risse, Jin-Ho Lee, Norbert Sewald, Volker F Wendisch

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Advances in the Study of Halogenated Natural Products.Current topics in medicinal chemistry · 2025
    Review
  5. Balance between photoreduction efficiency, cofactor affinity, and allosteric coupling of halogenase flavoenzymes.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Sustainable Production ofMicroorganisms · 2021
    Article
  15. Article
  16. Physiological Response ofMicroorganisms · 2020
    Article
  17. FermentativeMicroorganisms · 2020
    Article
  18. Fermentative Production ofFrontiers in bioengineering and biotechnology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kareen H VeldmannGenetics of Prokaryotes, Faculty of Biology & Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Steffen DachwitzOrganic and Bioorganic Chemistry, Faculty of Chemistry & Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Joe Max RisseFermentation Technology, Technical Faculty & Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Jin-Ho LeeMajor in Food Science and Biotechnology, School of Food Biotechnology and Nutrition, BB21+, Kyungsung University, Busan, South Korea.
Norbert SewaldOrganic and Bioorganic Chemistry, Faculty of Chemistry & Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Volker F WendischGenetics of Prokaryotes, Faculty of Biology & Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Bielefeld University · DEKyungsung University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brominated compounds such as 7-bromo-l-tryptophan (7-Br-Trp) occur in Nature. Many synthetic and natural brominated compounds have applications in the agriculture, food, and pharmaceutical industries, for example, the 20S-proteasome inhibitor TMC-95A that may be derived from 7-Br-Trp. Mild halogenation by cross-linked enzyme aggregates containing FAD-dependent halogenase, NADH-dependent flavin reductase, and alcohol dehydrogenase as well as by fermentation with recombinant

Indexed as

7-bromo-L-tryptophanamino acidsCorynebacteriumfermentationhalogenation

Identifiers

PMID31620432
PMCPMC6759940
OpenAlexW2971136151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.