Evidence map›Paper›PMID 31620364›Full record

ArticleFrontiers in oncology2019

Limited Utility of Circulating Cell-Free DNA Integrity as a Diagnostic Tool for Differentiating Between Malignant and Benign Thyroid Nodules With Indeterminate Cytology (Bethesda Category III).

Shilpa Thakur, Andrew Tobey, Brianna Daley, Sungyoung Auh, Mary Walter, Dhaval Patel, Naris Nilubol, Electron Kebebew, Aneeta Patel, Kirk Jensen and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00001160 (Studies on Thyroid Nodules and Thyroid Cancer), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00001160 recruitingnot on this map

Studies on Thyroid Nodules and Thyroid Cancer

TypeobservationalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran1977Enrolled2,500ConditionsHurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer, Follicular Thyroid Cancer, Thyroid CancerArms68-Gallium Dotatate
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Fragmentation Analysis of Plasma DNA Reveals Its Prognostic Value in Gastric Cancer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Shilpa ThakurMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Andrew TobeyMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Brianna DaleyMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Sungyoung AuhNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Mary WalterCore for Clinical Laboratory Services, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Dhaval PatelCancer Center - Froedtert Hospital, Milwaukee, WI, United States.
Naris NilubolEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Electron KebebewDivision of General Surgery, Endocrine Oncology Research Laboratory, Department of Surgery, Stanford Medicine, School of Medicine, Stanford, CA, United States.
Aneeta PatelDepartment of Pediatric Endocrinology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Kirk JensenDepartment of Pediatric Endocrinology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Vasyl VaskoDepartment of Pediatric Endocrinology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Joanna Klubo-GwiezdzinskaMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
National Institutes of Health · USUniformed Services University of the Health Sciences · USNational Institute of Diabetes and Digestive and Kidney Diseases · USFroedtert Hospital · USStanford Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AUS/FLUScirculating cell free DNAintegrityliquid biopsythyroid cancer

Identifiers

PMID31620364
PMCPMC6759775
OpenAlexW2970294659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.