Evidence map›Paper›PMID 31620359›Full record

ReviewFrontiers in oncology2019

Exosomes in Head and Neck Squamous Cell Carcinoma.

Cheng Xiao, Fang Song, Yu Long Zheng, Jiong Lv, Qiang Feng Wang, Nong Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheng XiaoDepartment of Medical Oncology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Fang SongDepartment of Anesthesiology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Yu Long ZhengDepartment of Medical Oncology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Jiong LvDepartment of Oral and Maxillofacial Surgery, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Qiang Feng WangDepartment of Medical Oncology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Nong XuDepartment of Medical Oncology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are small membranous vesicles that contain proteins, lipids, genetic material, and metabolites with abundant information from parental cells. Exosomes carry and deliver bioactive contents that can reprogram the functions of recipient cells and modulate the tumor microenvironment to induce pathological events through cell-to-cell communication and signal transduction. Tumor-derived exosomes (TDEs) in head and neck squamous cell carcinoma (HNSCC) are involved in most aspects of cancer initiation, invasion, progression, immunoregulation, therapeutic applications, and treatment resistance. In addition, HNSCC-derived exosomes can be used to obtain information on diagnostic and therapeutic biomarkers in circulating blood and saliva. Currently, the biology, mechanisms, and applications of TDEs in HNSCC are still unclear, and further research is required. In this review, we discuss various aspects of exosome biology, including exosomal components, exosomal biomarkers, and molecular mechanisms involved in immunoregulation, cancer metastasis, and therapy resistance. We also describe recent applications to update our understanding of exosomes in HNSCC.

Indexed as

biomarkersexosomeshead and neck squamous cell carcinomatherapy resistancetumor microenvironment

Identifiers

PMID31620359
PMCPMC6759986

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.