ArticleFrontiers in genetics2019
Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mutation in the GRIA4 Gene Presenting as ESES: Expanding the Genetic Landscape of ESES.Annals of Indian Academy of Neurology · 2024Article
- How to behave when marooned: the behavioural component of the island syndrome remains underexplored.Biology letters · 2022Review
- Review
- Spreading the Wealth: Developing Assessments of Cognitive Abilities in Non-WEIRD Countries.Integrative psychological & behavioral science · 2021Article
- Children's Greenness Exposure and IQ-Associated DNA Methylation: A Prospective Cohort Study.International journal of environmental research and public health · 2021Article
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Authors and funding
5 authors.
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Abstract
Recent studies of the genetic foundations of cognitive ability rely on large samples (in extreme, hundreds of thousands) of individuals from relatively outbred populations of mostly European ancestry. Hypothesizing that the genetic foundation of cognitive ability depends on the broader population-specific genetic context, we performed a genome-wide association study and homozygosity mapping of cognitive ability estimates obtained through latent variable modeling in a sample of 354 children from a consanguineous population of Saudi Arabia. Approximately half of the sample demonstrated significantly elevated homozygosity levels indicative of inbreeding, and among those with elevated levels, homozygosity was negatively associated with cognitive ability. Further homozygosity mapping identified a specific run, inclusive of the
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