ArticleFrontiers in immunology2019
Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 16 citations in OpenAlex.
- Compartment-specific regulation of stromal differentiation of the spleen in health and disease.Genes and immunity · 2026Review
- Review
- In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8GeroScience · 2026Article
- High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures.Nature communications · 2025Article
- Age-Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function.Aging cell · 2025Article
- Effects of PACAP Deficiency on Immune Dysfunction and Peyer's Patch Integrity in Adult Mice.International journal of molecular sciences · 2024Article
- Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice.Nature communications · 2024Article
- Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging.Seminars in immunology · 2023Review
- Aging of lymphoid stromal architecture impacts immune responses.Seminars in immunology · 2023Review
- Heterozygous OT-I mice reveal that antigen-specific CD8Aging cell · 2023Article
- The aging of the immune system and its implications for transplantation.GeroScience · 2023Review
- Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8Aging cell · 2022Article
- Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination.Nature communications · 2022Article
- Immune response to COVID-19 in older adults.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Immunity to acute virus infections with advanced age.Current opinion in virology · 2021Review
- Age-Related Dynamics of Lung-Resident Memory CD8Frontiers in immunology · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In response to infection with intracellular microorganisms, old mice mobilize decreased numbers of antigen-specific CD8 T cells with reduced expression of effector molecules and impaired cytolytic activity. Molecular mechanisms behind these defects and the cell-intrinsic (affecting naïve CD8 T cells themselves) vs. extrinsic, microenvironmental origin of such defects remain unclear. Using reciprocal transfer experiments of highly purified naïve T cells from adult and old transgenic OT-1 mice, we decisively show that the dominant effect is cell-extrinsic. Naïve adult OT-1 T cells failed to expand and terminally differentiate in the old organism infected with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.