ArticleFrontiers in neurology2019
Abnormal Functional Connectivity in Cognitive Control Network, Default Mode Network, and Visual Attention Network in Internet Addiction: A Resting-State fMRI Study.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- The neurobiology of internet addiction: a scoping review of developmental and gender-specific mechanisms.Frontiers in psychology · 2026Pooled it
- Pooled it
- Functional Neural Alterations in Pathological Internet Use: A Meta-Analysis of Neuroimaging Studies.Frontiers in neurology · 2022Pooled it
- Targeting Internet Addiction Through Body Awareness Psychotherapy: The Mediating Role of Executive Functions and Emotion Regulation.Brain and behavior · 2025Trial
- Solution-focused group counseling enhances attention control in Internet addiction: Behavioral and neural evidence.Dialogues in clinical neuroscience · 2026Article
- The Interplay Between Sleep Disturbance, Glymphatic Dysfunction and Altered Brain Networks in Internet Gaming Disorder: A Multimodal Neuroimaging Study.Addiction biology · 2026Article
- Connectome-based prediction of problematic use of social media in adolescents: Findings from the ABCD study.NeuroImage · 2026Article
- Internet addiction is associated with differences in static and dynamic hippocampal functional connectivity in young adults: the mediating role of emotion regulation difficulties.Frontiers in psychiatry · 2026Article
- MRI assessment of intrinsic neural timescales in male alcohol use disorder patients.Frontiers in psychiatry · 2026Article
- Adolescent Insomnia Disorder - Problematic Internet Use Nexus: A Convergent Developmental Trajectory - Bridging Neuroimaging Biomarkers, Molecular Susceptibility, and Environmental-Neurocognitive Cascades.Psychology research and behavior management · 2026Review
- A longitudinal study on the effect of aerobic exercise intervention on the inhibitory control in college students with internet addiction.Frontiers in human neuroscience · 2025Article
- Spatial Craving Patterns in Marijuana Users: Insights From fMRI Brain Connectivity Analysis With High-Order Graph Attention Neural Networks.IEEE journal of biomedical and health informatics · 2025Article
- Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Altered functional brain networks in problematic smartphone and social media use: resting-state fMRI study.Brain imaging and behavior · 2024Article
- Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto-parietal network in adolescents with internet addiction.Brain and behavior · 2023Article
- Disrupted Dynamic Functional Network Connectivity Among Cognitive Control Networks in the Progression of Alzheimer's Disease.Brain connectivity · 2023Article
- Intermittent energy restriction changes the regional homogeneity of the obese human brain.Frontiers in neuroscience · 2023Article
- Structural and Functional Neural Alterations in Internet Addiction: A Study Protocol for Systematic Review and Meta-Analysis.Psychiatry investigation · 2023Article
- Neural activations to loss anticipation mediates the association between difficulties in emotion regulation and screen media activities among early adolescent youth: A moderating role for depression.Developmental cognitive neuroscience · 2022Article
- Temporally dynamic neural correlates of drug cue reactivity, response inhibition, and methamphetamine-related response inhibition in people with methamphetamine use disorder.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Internet addiction (IA) has become a global mental and social problem, which may lead to a series of psychiatric symptoms including uncontrolled use of internet, and lack of concentration. However, the exact pathophysiology of IA remains unclear. Most of functional connectivity studies were based on pre-selected regions of interest (ROI), which could not provide a comprehensive picture of the communication abnormalities in IA, and might lead to limited or bias observations. Using local functional connectivity density (lFCD), this study aimed to explore the whole-brain abnormalities of functional connectivity in IA. We evaluated the whole-brain lFCD resulting from resting-state fMRI data in 28 IA individuals and 30 demographically matched healthy control subjects (HCs). The correlations between clinical characteristics and aberrant lFCD were also assessed. Compared with HCs, subjects with IA exhibited heightened lFCD values in the right dorsolateral prefrontal cortex (DLPFC), left parahippocampal gyrus (PHG), and cerebellum, and the bilateral middle cingulate cortex (MCC) and superior temporal pole (STP), as well as decreased lFCD values in the right inferior parietal lobe (IPL), and bilateral calcarine and lingual gyrus. Voxel-based correlation analysis revealed the significant correlations between the Young's Internet Addiction Test (IAT) score and altered lFCD values in the left PHG and bilateral STP. These findings revealed the hyper-connectivity in cognitive control network and default mode network as well as the hypo-connectivity in visual attention network, verifying the common mechanism in IA and substance addiction, and the underlying association between IA, and attention deficit/hyperactivity disorder in terms of neurobiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.