ArticleFrontiers in neurology2019
Peripheral Innate Immune Activation Correlates With Disease Severity in
Open access · goldAbstract read
In one paragraph
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 45% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Pooled it
- Targeting Granulin Haploinsufficiency in Frontotemporal Dementia: From Genetic Mechanisms to Therapeutics.International journal of molecular sciences · 2025Review
- ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses.Molecular neurodegeneration · 2025Article
- Investigating the role and regulation of GPNMB in progranulin-deficient macrophages.Frontiers in immunology · 2024Article
- Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease.Journal of neuroinflammation · 2023Review
- Immune cell counts in cerebrospinal fluid predict cognitive function in aging and neurodegenerative disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Emerging Trends in the Field of Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder.Biomedicines · 2023Review
- Clinical and Neuroimaging Aspects of Familial Frontotemporal Lobar Degeneration Associated with MAPT and GRN Mutations.Advances in experimental medicine and biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 1 country.
Peter A LjubenkovDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Zachary MillerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Paige MumfordDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Jane ZhangDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, United States.
Isabel Elaine AllenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
Laura MiticDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Adam StaffaroniDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Hilary HeuerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Julio C RojasDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Yann CobigoDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Anna KarydasDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Rodney PearlmanThe Bluefield Project to Cure Frontotemporal Dementia, San Francisco, CA, United States.
Bruce MillerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Joel H KramerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Michael S McGrathDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, United States.
Howard J RosenDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
Adam L BoxerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USUniversity Memory and Aging Center · US
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER, Bradley F Boeve · 2019 to 2026
$120.9MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Serggio Carlo Lanata · 2019 to 2026
$36.9MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MThe Frontotemporal Lobar Degeneration Neuroimaging InitiativeR01AG032306 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2009 to 2013
$10.0MMultidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4MTraining - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4MMultimodal Imaging in Frontotemporal DegenerationK24AG045333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2013 to 2023
$1.9MProteomics for fluid biomarker discovery in frontotemporal dementiaK23AG059888 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROJAS-MARTINEZ, JULIO CESAR · 2019 to 2023
$995kNIA NIH HHS K23 AG059888NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG032306NIA NIH HHS T32 AG023481NIA NIH HHS U01 AG045390NIA NIH HHS U19 AG063911NINDS NIH HHS U54 NS092089
Abstract
PubMed holds no abstract for this paper.
Indexed as
frontotemperal lobar degenerationinnate immune systemmonocyteperipheral immune activationprogranulin (GRN)
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.