ArticleFrontiers in physiology2019
Multiple Hits in Acute Pancreatitis: Components of Metabolic Syndrome Synergize Each Other's Deteriorating Effects.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04647097 (Recurrent Acute Pancreatitis Prevention by the Elimination of Alcohol and Cigarette Smoking), which is not on this map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recurrent Acute Pancreatitis Prevention by the Elimination of Alcohol and Cigarette Smoking (REAPPEAR): Protocol of a Randomized Controlled Trial and a Cohort Study
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Metabolic syndrome components individually worsen the outcome of acute pancreatitis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Chronic liver disease is an important risk factor for worse outcomes in acute pancreatitis: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Predictive value of adipokines for the severity of acute pancreatitis: a meta-analysis.BMC gastroenterology · 2024Pooled it
- Risk factors for diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- Development and validation of a risk prediction score for the severity of acute hypertriglyceridemic pancreatitis in Chinese patients.World journal of gastroenterology · 2022Trial
- Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality.Scientific reports · 2021Trial
- Risk spectrum of admission HbA1c levels and acute pancreatitis severity: a real-world study revealing younger high-risk populations and nonlinear associations.Annals of medicine · 2026Article
- New Perspectives in the Assessment of Severity Scoring in Acute Pancreatitis: Development and Internal Validation of a Novel Bedside Prognostic Score (ProbScore2).Medicina (Kaunas, Lithuania) · 2026Observational
- MASLD and Pancreatic Diseases: From Shared Mechanisms to Clinical Implications and Future Directions.Nutrients · 2026Review
- Development of a prediction method for severe pancreatitis using a nomogram.Frontiers in medicine · 2026Article
- Glucagon-Like Peptide-1 Analogues and the Risk of Recurrent Pancreatitis in Diabetic Patients With History of Pancreatitis or Elevated Lipase: Retrospective Cohort Analysis.Diabetes/metabolism research and reviews · 2026Article
- Pleural effusion within 24 h of admission predicts severe hypertriglyceridemia-induced acute pancreatitis and organ failure: retrospective cohort of 296 patients.Frontiers in medicine · 2026Article
- Review
- From NAFPD to MAFPD: a literature review of implications of a nomenclature change.Hepatobiliary surgery and nutrition · 2025Review
- Euglycemic diabetic ketoacidosis associated with etogliflozin in post-pancreatitis diabetes: A case report.World journal of clinical cases · 2025Article
- The 12-Year Experience of the Hungarian Pancreatic Study Group.Journal of clinical medicine · 2025Review
- Outcomes of Acute Pancreatitis in Patients With and Without Liver Cirrhosis: A Retrospective Analysis.Cureus · 2025Article
- The value of NLR, PLR, PCT, and D-D levels in assessing the severity of hyperlipidemic acute pancreatitis.Frontiers in medicine · 2025Article
- Metabolic syndrome and acute pancreatitis: Current status and future prospects.World journal of gastroenterology · 2024Review
- Impact of metabolic syndrome components on clinical outcomes in hypertriglyceridemia-induced acute pancreatitis.World journal of gastroenterology · 2024Article
Corrections and comments
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Authors and funding
26 authors at 11 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe incidence of acute pancreatitis (AP) and the prevalence of metabolic syndrome (MetS) are growing worldwide. Several studies have confirmed that obesity (OB), hyperlipidemia (HL), or diabetes mellitus (DM) can increase severity, mortality, and complications in AP. However, there is no comprehensive information on the independent or joint effect of MetS components on the outcome of AP. Our aims were (1) to understand whether the components of MetS have an independent effect on the outcome of AP and (2) to examine the joint effect of their combinations.
methodsFrom 2012 to 2017, 1435 AP cases from 28 centers were included in the prospective AP Registry. Patient groups were formed retrospectively based on the presence of OB, HL, DM, and hypertension (HT). The primary endpoints were mortality, severity, complications of AP, and length of hospital stay. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated.
results1257 patients (55.7 ± 17.0 years) were included in the analysis. The presence of OB was an independent predictive factor for renal failure [OR: 2.98 (CI: 1.33-6.66)] and obese patients spent a longer time in hospital compared to non-obese patients (12.1 vs. 10.4 days,
conclusionOB, HT, and HL are independent risk factors for a number of complications. HT is an independent risk factor for severity as well. Components of MetS strongly synergize each other's detrimental effect. It is important to search for and follow up on the components of MetS in AP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.