ArticleFrontiers in physiology2019
Sense of Smell as the Central Driver of Pavlovian Appetite Behavior in Mammals.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Age-related changes in olfactory function: electrophysiological recordings from the olfactory mucosa and human brain.npj aging · 2026Article
- Chocolate odor enhances resistance exercise performance through appetite suppression in the fasted state: an exploratory study.Frontiers in physiology · 2026Article
- Olfactory Capacity and Obesity in Chilean Adolescents.Nutrients · 2025Article
- GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice.Journal of neuroendocrinology · 2025Article
- A food-sensitive olfactory circuit drives anticipatory satiety.Nature metabolism · 2025Article
- Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism.Molecular metabolism · 2024Article
- Olfactory bulb anomalies in KBG syndrome mouse model and patients.BMC medicine · 2024Article
- Review
- [An Integrated Audio-Visual-Olfactory Virtual Reality False Feeding Device: Research, Development, and Design].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- OWSum: algorithmic odor prediction and insight into structure-odor relationships.Journal of cheminformatics · 2023Article
- Utilization of ethanolamine phosphate phospholyase as a unique astrocytic marker.Frontiers in cellular neuroscience · 2023Article
- Appetite-regulating hormones modulate odor perception and odor-evoked activity in hypothalamus and olfactory cortices.Chemical senses · 2023Article
- The role of food odor in invertebrate foraging.Genes, brain, and behavior · 2022Review
- The Orexigenic Force of Olfactory Palatable Food Cues in Rats.Nutrients · 2021Article
- Olfactory impairment in men and mice related to aging and amyloid-induced pathology.Pflugers Archiv : European journal of physiology · 2021Review
- Article
- Unraveling the Role of Dopaminergic and Calretinin Interneurons in the Olfactory Bulb.Frontiers in neural circuits · 2021Review
- The Transformative Influence of La Varenne'sFrontiers in nutrition · 2020Article
- Gastronomic Paradigms in Contemporary Western Cuisine: From French Haute Cuisine to Mass Media Gastronomy.Frontiers in nutrition · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The seminal experiments of Ivan Petrovich Pavlov set the stage for an understanding of the physiological concomitants of appetite and feeding behavior. His findings, from careful and creative experimentation, have been uncontested for over a century. One of Pavlov's most fundamental observations was that activation of salivary, gastric and pancreatic secretions during feeding and sham-feeding, precedes entry of food into the mouth, generating signals to the brain from various sensory pathways. Pavlov referred to this as the "psychic" phase of digestion. However, quite surprisingly, he did not attempt to isolate any single sensory system as the main driver of this phenomenon. Herein we revisit Pavlov's findings and hypothesize that the evolutionarily-important sense of smell is the pathway most-likely determinant of feeding behavior in mammals. Substantial understandings of olfactory receptors and their neural pathways in the central nervous system have emerged over the past decade. Neurogenic signals, working in concert with hormonal inputs are described, illustrating the ways in which sense of smell determines food-seeking and food-preference. Additionally, we describe how sense of smell affects metabolic pathways relevant to energy metabolism, hunger and satiety as well as a broad range of human behaviors, thereby reinforcing its central biological role in mammals. Intriguing possibilities for future research, based upon this hypothesis, are raised.
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