Evidence map›Paper›PMID 31619997›Full record

ArticleFrontiers in pharmacology2019

Evidence for Arrhythmogenic Effects of A

Peter Boknik, Katharina Drzewiecki, John Eskandar, Ulrich Gergs, Britt Hofmann, Hendrik Treede, Stephanie Grote-Wessels, Larissa Fabritz, Paulus Kirchhof, Lisa Fortmüller and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Studies on the mechanisms of action of MR33317.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  4. Article
  5. Article
  6. Cardiovascular effects of bufotenin on human 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Amitriptyline functionally antagonizes cardiac HNaunyn-Schmiedeberg's archives of pharmacology · 2021
    Article
  11. Influence of Serotonin 5-HTBiomedicines · 2021
    Article
  12. Adenosine AInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Review
  15. Role of Cardiac AFrontiers in pharmacology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Peter BoknikInstitut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
Katharina DrzewieckiInstitut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
John EskandarInstitut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
Ulrich GergsInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Britt HofmannKlinik für Herzchirurgie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Hendrik TreedeKlinik für Herzchirurgie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Stephanie Grote-WesselsInstitut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
Larissa FabritzInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom.
Paulus KirchhofInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom.
Lisa FortmüllerInstitute for Human Genetics, Genetic epidemiology, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
Frank Ulrich MüllerInstitut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
Wilhelm SchmitzInstitut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
Norbert ZimmermannBundesinstitut für Arzneimittel und Medizinprodukte, Bonn, Germany.
Uwe KirchheferInstitut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
Joachim NeumannInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
University of Münster · DEMartin Luther University Halle-Wittenberg · DEUniversity Hospital Münster · DEFederal Institute for Drugs and Medical Devices · DESandwell & West Birmingham Hospitals NHS Trust · GBUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenosine can be released from the heart and may stimulate four different cardiac adenosine receptors. A receptor subtype that couples to the generation of cyclic adenosine monophosphate (cAMP) is the A

Indexed as

A2A-adenosine receptorarrhythmiascontractilityhuman heartischemiareperfusion

Identifiers

PMID31619997
PMCPMC6759833
OpenAlexW2966952499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.