ArticleFrontiers in neural circuits2019
Why Isn't the Head Direction System Necessary for Direction? Lessons From the Lateral Mammillary Nuclei.
Article in Frontiers in neural circuits, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types.bioRxiv : the preprint server for biology · 2026Article
- Electrophysiological Properties of the Medial Mammillary Bodies across the Sleep-Wake Cycle.eNeuro · 2024Article
- Time to retire the serial Papez circuit: Implications for space, memory, and attention.Neuroscience and biobehavioral reviews · 2022Review
- Construction of complex memories via parallel distributed cortical-subcortical iterative integration.Trends in neurosciences · 2022Review
- Anterior Thalamic Inputs Are Required for Subiculum Spatial Coding, with Associated Consequences for Hippocampal Spatial Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The anterior thalamic nuclei and cognition: A role beyond space?Neuroscience and biobehavioral reviews · 2021Review
- Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021Review
- The anterior thalamic nuclei and nucleus reuniens: So similar but so different.Neuroscience and biobehavioral reviews · 2020Review
- Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus.eLife · 2020Article
- Deconstructing the Direct Reciprocal Hippocampal-Anterior Thalamic Pathways for Spatial Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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2 authors.
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Abstract
Complex spatial representations in the hippocampal formation and related cortical areas require input from the head direction system. However, a recurrent finding is that behavior apparently supported by these spatial representations does not appear to require input from generative head direction regions, i.e., lateral mammillary nuclei (LMN). Spatial tasks that tax direction discrimination should be particularly sensitive to the loss of head direction information, however, this has been repeatedly shown not to be the case. A further dissociation between electrophysiological properties of the head direction system and behavior comes in the form of geometric-based navigation which is impaired following lesions to the head direction system, yet head direction cells are not normally guided by geometric cues. We explore this apparent mismatch between behavioral and electrophysiological studies and highlight future experiments that are needed to generate models that encompass both neurophysiological and behavioral findings.
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