ArticleCell research2020
Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.
Article in Cell research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Phospholipases D: An Update on Structure-Function Relationships.Methods in molecular biology (Clifton, N.J.) · 2027Review
- Phosphatidic acid-driven plasma membrane localization and activation of FER confer salt tolerance inScience advances · 2026Article
- Prenatal psychological stress mediates vertical transmission of gut microbiome to the next generation affecting offspring depressive-like behaviors and neurotransmitter.BMC psychology · 2025Article
- Exploration of the pearl millet phospholipase gene family to identify potential candidates for grain quality traits.BMC genomics · 2024Article
- Phospholipid Signaling in Crop Plants: A Field to Explore.Plants (Basel, Switzerland) · 2024Article
- Genome-Wide Investigation of the PLD Gene Family in Tomato: Identification, Analysis, and Expression.Genes · 2024Article
- Phosphatidic acid produced by phospholipase Dα1 and Dδ is incorporated into the internal membranes but not involved in the gene expression ofFrontiers in plant science · 2024Article
- Human SIDT1 mediates dsRNA uptake via its phospholipase activity.Cell research · 2024Article
- Major-effect quantitative trait locus qLKR4.1 encodes a phospholipase Dδ protein associated with low-KTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Article
- Structural insights into PA3488-mediated inactivation of Pseudomonas aeruginosa PldA.Nature communications · 2022Article
- A New Phospholipase D fromInternational journal of molecular sciences · 2022Article
- The catalytic and structural basis of archaeal glycerophospholipid biosynthesis.Extremophiles : life under extreme conditions · 2022Review
- The functions of phospholipases and their hydrolysis products in plant growth, development and stress responses.Progress in lipid research · 2022Review
- Characterization and evolutionary diversification of the phospholipase D gene family in mosses.Frontiers in genetics · 2022Article
- Attracted to membranes: lipid-binding domains in plants.Plant physiology · 2021Article
- Functional and Structural Investigation of Chalcone Synthases Based on Integrated Metabolomics and Transcriptome Analysis on Flavonoids and Anthocyanins Biosynthesis of the FernFrontiers in plant science · 2021Article
- Structure and regulation of human phospholipase D.Advances in biological regulation · 2021Review
- The Plasma Membrane-An Integrating Compartment for Mechano-Signaling.Plants (Basel, Switzerland) · 2020Review
- PLD2-PI(4,5)P2 interactions in fluid phase membranes: Structural modeling and molecular dynamics simulations.PloS one · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phospholipase D (PLD) hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid (PA), which acts as a second messenger in many living organisms. A large number of PLDs have been identified in eukaryotes, and are viewed as promising targets for drug design because these enzymes are known to be tightly regulated and to function in the pathophysiology of many human diseases. However, the underlying molecular mechanisms of catalysis and regulation of eukaryotic PLD remain elusive. Here, we determined the crystal structure of full-length plant PLDα1 in the apo state and in complex with PA. The structure shows that the N-terminal C2 domain hydrophobically interacts with the C-terminal catalytic domain that features two HKD motifs. Our analysis reveals the catalytic site, substrate-binding mechanism, and a new Ca
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