Evidence map›Paper›PMID 31619748›Full record

ArticleThe pharmacogenomics journal2020

Pharmacogenetic determinants of kidney-associated urinary and serum abnormalities in antiretroviral-treated HIV-positive patients.

Jessica Cusato, Andrea Calcagno, Letizia Marinaro, Valeria Avataneo, Antonio DʹAvolio, Giovanni Di Perri, Stefano Bonora

Abstract read
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jessica CusatoDepartment of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy. jessica.cusato@unito.it.
Andrea CalcagnoDepartment of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.ORCID http://orcid.org/0000-0003-2534-8815
Letizia MarinaroDepartment of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
Valeria AvataneoDepartment of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
Antonio DʹAvolioDepartment of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
Giovanni Di PerriDepartment of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
Stefano BonoraDepartment of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
Ospedale Amedeo di Savoia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tenofovir disoproxyl fumarate (TDF) has been associated with renal tubular abnormalities, phosphaturia and proteinuria (retinol binding protein, RBP, loss): vitamin D (VD) and PTH affect these markers. Aim was to understand if some single nucleotide polymorphisms (SNPs) were predictors of renal abnormalities in an Italian cohort of HIV-affected patients. DNA was analyzed through real-time PCR, urinary RBP corrected by creatinine (uRBP/Cr). The majority of patients received TDF. Abnormal uRBP/Cr was more frequent in TDF recipients: eGFR <90 mL/min and TDF were predictors in the whole cohort, whereas eGFR <90 mL/min, TDF concentrations and CYP24A1-3999TT in TDF-treated patients. Phosphate levels were higher low VD level patients: age <50 years, CYP27B1 + 2838CC genotype and non-European ancestry were predictors. PTH levels were border-line higher in TDF patients: non-European ancestry, females, TDF, VD levels < 30 ng/mL and SLC28A2-124CT/TT and ABCC2-24CC were predictors. For the first time, SNPs were associated with PTH, phosphate, calcium and tubular dysfunction in HIV-infected patients.

Indexed as

Polymorphism, Single NucleotideAdultAnti-HIV AgentsATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BCohort StudiesCreatinineFemaleGlomerular Filtration RateHIV InfectionsHumansKidney DiseasesLogistic ModelsMaleMiddle AgedMultidrug Resistance-Associated Protein 2ABCB1 protein, humanABCC10 protein, humanABCC2 protein, humanAnti-HIV AgentsATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BCreatinineCYP24A1 protein, humanMultidrug Resistance-Associated Protein 2PhosphatesReceptors, CalcitriolRetinol-Binding ProteinsTenofovirVDR protein, humanVitamin D3 24-Hydroxylase

Identifiers

PMID31619748
OpenAlexW2980729498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.