ArticleNature communications2019
Epi-illumination gradient light interference microscopy for imaging opaque structures.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Scattering-enabled epi-quantitative phase imaging reveals subcellular detail in organoids and deep mouse brains.bioRxiv : the preprint server for biology · 2026Article
- Back-illumination interference tomography for imaging weak scattering in thick tissues.Optica · 2025Article
- Review
- Novel imaging and biophysical approaches to study tissue hydraulics in mammalian folliculogenesis.Biophysical reviews · 2024Review
- Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids.Scientific reports · 2024Article
- Label-free, high-throughput holographic imaging to evaluate mammalian gametes and embryos†.Biology of reproduction · 2024Review
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part I.Journal of biomedical optics · 2024Review
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part II.Journal of biomedical optics · 2024Review
- Capturing cell morphology dynamics with high temporal resolution using single-shot quantitative phase gradient imaging.Journal of biomedical optics · 2024Article
- Vibrational imaging of metabolites for improved microbial cell strains.Journal of biomedical optics · 2024Review
- Multispectral Holographic Intensity and Phase Imaging of Semitransparent Ultrathin Films.ACS photonics · 2024Article
- Non-Invasive Label-free Analysis Pipeline for In Situ Characterization of Differentiation in 3D Brain Organoid Models.Research square · 2024Article
- Towards ultrafast quantitative phase imaging via differentiable microscopy [Invited].Biomedical optics express · 2024Article
- Fast Fourier ptychographic quantitative phase microscopy for in vitro label-free imaging.Biomedical optics express · 2024Article
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Viewing life without labels under optical microscopes.Communications biology · 2023Review
- Single-shot isotropic differential interference contrast microscopy.Nature communications · 2023Article
- Artificial confocal microscopy for deep label-free imaging.Nature photonics · 2023Article
- White blood cell detection, classification and analysis using phase imaging with computational specificity (PICS).Scientific reports · 2022Article
- Circadian Volume Changes in Hippocampal Glia Studied by Label-Free Interferometric Imaging.Cells · 2022Article
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Authors and funding
11 authors.
Funding
Abstract
Multiple scattering and absorption limit the depth at which biological tissues can be imaged with light. In thick unlabeled specimens, multiple scattering randomizes the phase of the field and absorption attenuates light that travels long optical paths. These obstacles limit the performance of transmission imaging. To mitigate these challenges, we developed an epi-illumination gradient light interference microscope (epi-GLIM) as a label-free phase imaging modality applicable to bulk or opaque samples. Epi-GLIM enables studying turbid structures that are hundreds of microns thick and otherwise opaque to transmitted light. We demonstrate this approach with a variety of man-made and biological samples that are incompatible with imaging in a transmission geometry: semiconductors wafers, specimens on opaque and birefringent substrates, cells in microplates, and bulk tissues. We demonstrate that the epi-GLIM data can be used to solve the inverse scattering problem and reconstruct the tomography of single cells and model organisms.
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