ArticleNature communications2019
Bypassing stroke-damaged neural pathways via a neural interface induces targeted cortical adaptation.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07610850 (Brain-controlled Spinal Cord Stimulation in Participants With Chronic Stroke for Lower and Upper Limb Rehabilitation), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain-controlled Spinal Cord Stimulation in Participants With Chronic Stroke for Lower and Upper Limb Rehabilitation
Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Review of Recent Advances in Implantable Brain-Computer Interfaces for the Restoration of Motor Function in Patients With Paralysis.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Non-invasive closed-loop spinal stimulation restores leg stepping control in humans with paraplegia.Brain : a journal of neurology · 2026Article
- Cortical activation of neuromuscular electrical stimulation synchronized mirror neuron rehabilitation strategies: an fNIRS study.Frontiers in neurology · 2023Article
- Corticospinal interface to restore voluntary control of joint torque in a paralyzed forearm following spinal cord injury in non-human primates.Frontiers in neuroscience · 2023Article
- Does brain activity cause consciousness? A thought experiment.PLoS biology · 2022Article
- Preserved cortical somatotopic and motor representations in tetraplegic humans.Current opinion in neurobiology · 2022Review
- Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation.Frontiers in human neuroscience · 2022Article
- Non-invasive brain-spine interface: Continuous control of trans-spinal magnetic stimulation using EEG.Frontiers in bioengineering and biotechnology · 2022Article
- Neuromotor prosthetic to treat stroke-related paresis: N-of-1 trial.Communications medicine · 2022Article
- Spinal Cord Injury-Induced Changes in Encoding and Decoding of Bipedal Walking by Motor Cortical Ensembles.Brain sciences · 2021Article
- Why brain-controlled neuroprosthetics matter: mechanisms underlying electrical stimulation of muscles and nerves in rehabilitation.Biomedical engineering online · 2020Review
- Adaptive self-healing electronic epineurium for chronic bidirectional neural interfaces.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regaining the function of an impaired limb is highly desirable in paralyzed individuals. One possible avenue to achieve this goal is to bridge the interrupted pathway between preserved neural structures and muscles using a brain-computer interface. Here, we demonstrate that monkeys with subcortical stroke were able to learn to use an artificial cortico-muscular connection (ACMC), which transforms cortical activity into electrical stimulation to the hand muscles, to regain volitional control of a paralysed hand. The ACMC induced an adaptive change of cortical activities throughout an extensive cortical area. In a targeted manner, modulating high-gamma activity became localized around an arbitrarily-selected cortical site controlling stimulation to the muscles. This adaptive change could be reset and localized rapidly to a new cortical site. Thus, the ACMC imparts new function for muscle control to connected cortical sites and triggers cortical adaptation to regain impaired motor function after stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.