Evidence map›Paper›PMID 31619558›Full record

ArticleJournal of virology2020

CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas.

Kati Tormanen, Shaohui Wang, Homayon Ghiasi

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Berberine Inhibits Herpes Simplex Virus 1 Replication in HEK293T Cells.Computational and mathematical methods in medicine · 2022
    Article
  7. Article
  8. Article
  9. Systemic diseases and the cornea.Experimental eye research · 2021
    Review
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kati TormanenCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC-SSB3, Los Angeles, California, USA.
Shaohui WangCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC-SSB3, Los Angeles, California, USA.
Homayon GhiasiCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC-SSB3, Los Angeles, California, USA ghiasih@CSHS.org.
Cedars-Sinai Medical Center · US

Funding

The Role of gK in HSV-1 Induced Corneal ScarringR01EY013615 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2002 to 2026
$7.8M
Role of Macrophages in control of Ocular HSVR01EY024649 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2015 to 2026
$4.1M
Therapeutic control of HSK by CD80R01EY026944 · NEI · CEDARS-SINAI MEDICAL CENTER · PI GHIASI, HOMAYON · 2016 to 2025
$3.9M
Ocular HSV: Mechanism of virus reactivationR01EY029160 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2018 to 2026
$3.4M
NEI NIH HHS R01 EY013615NEI NIH HHS R01 EY024649NEI NIH HHS R01 EY026944NEI NIH HHS R01 EY029160
6 · The paper itself

Abstract

We recently reported that herpes simplex virus 1 (HSV-1) infection suppresses CD80 but not CD86 expression

Indexed as

B7-1 AntigenCorneaHerpesvirus 1, HumanKeratitis, HerpeticSignal TransductionAnimalsApoptosis Regulatory ProteinsCD8-Positive T-LymphocytesDendritic CellsFemaleInflammationInterleukin-1MiceMice, Inbred BALB CRabbitsRNA-Binding ProteinsApoptosis Regulatory ProteinsB7-1 AntigenIfit2 protein, mouseInterleukin-1RNA-Binding Proteinscornealatency reactivationoculartranscriptomeviral transcriptsvirus replication

Identifiers

PMID31619558
PMCPMC6955247
OpenAlexW2981300855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.