ArticleScience translational medicine2019
Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation.
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Neuropeptide S modulation of learning and memory: a systematic review.Behavioral and brain functions : BBF · 2026Pooled it
- Emerging genetics of sleep and circadian disorders.Current opinion in pediatrics · 2026Article
- Not Quite Folded: Challenges in Predicting the hNPS-hNPSR-Ile107 Complex With AlphaFold2 Multimer.ChemMedChem · 2026Article
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- Electrophysiological characterization of neuropeptide S-expressing neurons in the periLC: influence of the female estrous cycle on neuronal excitability in mice.Pflugers Archiv : European journal of physiology · 2026Article
- JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish.iScience · 2026Article
- Nps-Expressing Neurons Receive Extensive Input From Auditory Brainstem Nuclei.The Journal of comparative neurology · 2026Article
- Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.The Journal of clinical investigation · 2026Article
- NPS neurons receive extensive input from auditory brainstem nuclei.bioRxiv : the preprint server for biology · 2025Article
- A familial natural short sleep mutation iniScience · 2025Article
- Rare variants inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The SIK3-N783Y mutation is associated with the human natural short sleep trait.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Decoding Multifaceted Roles of Sleep-Related Genes as Molecular Bridges in Chronic Disease Pathogenesis.International journal of molecular sciences · 2025Review
- Review
- Circadian Regulation in Diurnal Mammals: Neural Mechanisms and Implications in Translational Research.Biology · 2024Review
- The Influence of the Estrous Cycle on Neuropeptide S Receptor-Mediated Behaviors.The Journal of pharmacology and experimental therapeutics · 2024Article
- Article
- The new science of sleep: From cells to large-scale societies.PLoS biology · 2024Article
- Efferent projections of Nps-expressing neurons in the parabrachial region.The Journal of comparative neurology · 2024Article
- Sleep disturbance in Angelman syndrome patients.Orphanet journal of rare diseases · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Sleep is a crucial physiological process for our survival and cognitive performance, yet the factors controlling human sleep regulation remain poorly understood. Here, we identified a missense mutation in a G protein-coupled neuropeptide S receptor 1 (NPSR1) that is associated with a natural short sleep phenotype in humans. Mice carrying the homologous mutation exhibited less sleep time despite increased sleep pressure. These animals were also resistant to contextual memory deficits associated with sleep deprivation. In vivo, the mutant receptors showed increased sensitivity to neuropeptide S exogenous activation. These results suggest that the NPS/NPSR1 pathway might play a critical role in regulating human sleep duration and in the link between sleep homeostasis and memory consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.