Evidence map›Paper›PMID 31619516›Full record

ArticleThe Journal of biological chemistry2019

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.

Bruce J MacLachlan, Garry Dolton, Athanasios Papakyriakou, Alexander Greenshields-Watson, Georgina H Mason, Andrea Schauenburg, Matthieu Besneux, Barbara Szomolay, Tim Elliott, Andrew K Sewell and 4 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Impact of HLA-DR Antigen Binding Cleft Rigidity on T Cell Recognition.International journal of molecular sciences · 2020
    Article
  7. Differential gene expression of tumor-infiltrating CD8Journal for immunotherapy of cancer · 2020
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Bruce J MacLachlanDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0002-2685-2733
Garry DoltonDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Athanasios PapakyriakouInstitute of Biosciences and Applications, NCSR "Demokritos," Agia Paraskevi, 15341 Athens, Greece.ORCID 0000-0003-3931-6232
Alexander Greenshields-WatsonDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0002-8740-9823
Georgina H MasonDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Andrea SchauenburgDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0003-3561-2077
Matthieu BesneuxDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Barbara SzomolayDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0002-5375-5533
Tim ElliottInstitute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom.ORCID 0000-0003-1097-0222
Andrew K SewellDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0003-3194-3135
Awen GallimoreDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0001-6675-7004
Pierre RizkallahDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0002-9290-0369
David K ColeDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0003-0028-9396
Andrew GodkinDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom GodkinAJ@cardiff.ac.uk.ORCID 0000-0002-1910-7567
Cardiff University · GBNational Centre of Scientific Research "Demokritos" · GRUniversity Hospital of Wales · GBUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

Cancer Research UK 16997Cancer Research UK 21200Wellcome Trust
6 · The paper itself

Abstract

CD4

Indexed as

Amino Acid SequenceBinding SitesCD4-Positive T-LymphocytesColorectal NeoplasmsCrystallography, X-RayEpitopesHLA-DR1 AntigenHumansMembrane GlycoproteinsMolecular Dynamics SimulationPeptidesProtein BindingProtein Structure, SecondaryProtein Structure, TertiaryEpitopesHLA-DR1 AntigenMembrane GlycoproteinsPeptidestrophoblastic glycoprotein 5T4, humanantigen presentationantigen recognitioncrystallographymolecular dynamicspeptide flanking residuesstructure-functionT-cell biologytumor immunology

Identifiers

PMID31619516
PMCPMC6937582
OpenAlexW2980842125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.