Evidence map›Paper›PMID 31619456›Full record

ArticleThe Journal of general physiology2019

Unique structural features in an Nramp metal transporter impart substrate-specific proton cotransport and a kinetic bias to favor import.

Aaron T Bozzi, Lukas B Bane, Christina M Zimanyi, Rachelle Gaudet

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Determinants of metal import and specificity in a bacterial transporter.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. In vitro reconstitution of transition metal transporters.The Journal of biological chemistry · 2024
    Review
  12. Article
  13. Review
  14. Iron transport pathways in the human malaria parasiteFrontiers in cellular and infection microbiology · 2024
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aaron T BozziDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA.
Lukas B BaneDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA.
Christina M ZimanyiDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA.
Rachelle GaudetDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA gaudet@mcb.harvard.edu.ORCID 0000-0002-9177-054X
Harvard University · US

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Mechanism of Divalent Metal Transport by NRamp-Family TransportersR01GM120996 · NIGMS · HARVARD UNIVERSITY · PI GAUDET, RACHELLE · 2017 to 2024
$3.0M
NIGMS NIH HHS R01 GM120996
6 · The paper itself

Abstract

Natural resistance-associated macrophage protein (Nramp) transporters enable uptake of essential transition metal micronutrients in numerous biological contexts. These proteins are believed to function as secondary transporters that harness the electrochemical energy of proton gradients by "coupling" proton and metal transport. Here we use the

Indexed as

Bacterial ProteinsBiological TransportCation Transport ProteinsDeinococcusIon TransportKineticsManganeseMembrane PotentialsMetalsNatural Resistance-associated Macrophage Protein 1ProtonsBacterial ProteinsCation Transport ProteinsManganeseMetalsNatural Resistance-associated Macrophage Protein 1Protons

Identifiers

PMID31619456
PMCPMC6888756
OpenAlexW2980663528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.