Evidence map›Paper›PMID 31619433›Full record

Observational studyBMJ open2019

Associations between the SHARE frailty phenotype and common frailty characteristics: evidence from a large Danish population study.

Katja Kemp Jacobsen, Randi Jepsen, Maurice A Lembeck, Charlotte Nilsson, Ellen Holm

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02482896 (The Lolland-Falster Health Study), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02482896 unknown statusnot on this map

The Lolland-Falster Health Study

TypeobservationalSponsorRegion SjællandRan2016 to 2019Enrolled25,000ConditionsImpaired Health, Disease, Wellbeing, Mental Disorders
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katja Kemp JacobsenLolland-Falster Helath Study, Nykøbing F Sygehus, Nykobing, Denmark.
Randi JepsenLolland-Falster Helath Study, Nykøbing F Sygehus, Nykobing, Denmark.
Maurice A LembeckMedical Department, Nykobing F Sygehus, Nykobing Falster, Denmark.
Charlotte NilssonDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Ellen HolmInternal Medicine, Nykøbing F Sygehus, Nykobing, Denmark ellh@regionsjaelland.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesFrailty is a major clinical geriatric syndrome associated with serious adverse events including functional disability, falls, hospitalisation, increased morbidity and mortality. The aim of this study was to study associations between a frailty phenotype and frailty characteristics well known from the literature.

designRegistry-based cross-sectional study.

settingThe target population consists of inhabitants above the age of 50 living in the Danish municipalities of Lolland and Guldborgsund. Excluded are incapacitated people, inhabitants unable to understand Danish or English and inhabitants without a permanent residence.

participants7327 individuals aged 50+ years were included. OUTCOME MEASURES: We examined associations between the frailty measurement and factors known to be associated with frailty: sex, age, income insufficiency, education, comorbidity, self-assessed health, morbidity and mortality.

results7327 individuals aged 50+ years were included. Of these, 6.5% had ≥3 frailty components (frail), 46.7% had 1-2 components (prefrail) and 46.9% had none (non-frail). Those who were frail were older and more likely female than those who were non-frail or prefrail. There was a stepwise decrease in educational level, and in self-assessed health with increasing frailty status, and a stepwise increase in difficulty in making ends meet, number of hospital contacts and mortality with increasing frailty status, p<0.0001 for each comparison. Compared with individuals who were non-frail, mortality was higher among those who were prefrail (HR: 2.90; 95% CI: 1.30 to 6.43) or frail (HR: 8.21; 95% CI: 3.37 to 20.0).

conclusionsBased on these findings, we consider the Lolland-Falster Health Study frailty assessment a valid instrument demonstrating the same characteristics as other validated frailty measures concerning associations with sex, age, income insufficiency, education, comorbidity, self-assessed health, morbidity and mortality. TRIAL REGISTRATION NUMBER: NCT02482896.

Indexed as

AgedAged, 80 and overComorbidityCross-Sectional StudiesDenmarkFemaleFrail ElderlyGeriatric AssessmentHospitalizationHumansIndependent LivingMaleMiddle AgedMorbidityMortalityPhenotypefrailtyhealthy ageingphysical functional performance

Identifiers

PMID31619433
PMCPMC6797251

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.