Evidence map›Paper›PMID 31619404›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

The Association between the Comprehensive Epstein-Barr Virus Serologic Profile and Endemic Burkitt Lymphoma.

Anna E Coghill, Carla Proietti, Zhiwei Liu, Lutz Krause, Jeff Bethony, Ludmila Prokunina-Olsson, Adeola Obajemu, Francis Nkrumah, Robert J Biggar, Kishor Bhatia and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Plasma metabolites in childhood Burkitt lymphoma cases and cancer-free controls in Uganda.Metabolomics : Official journal of the Metabolomic Society · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Identifying Epstein-Barr virus peptide sequences associated with differential IgG antibody response.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  17. Identification of anti-Epstein-Barr virus (EBV) antibody signature in EBV-associated gastric carcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021
    Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Anna E Coghill *Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland. anna.coghill@moffitt.org.
Carla Proietti *Center for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.
Zhiwei LiuInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.ORCID 0000-0002-0136-651X
Lutz KrauseUniversity of Queensland, Diamantina Institute, Brisbane, Australia.
Jeff BethonyGeorge Washington University School of Medicine and Health Sciences, Washington, D.C.
Ludmila Prokunina-OlssonLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.ORCID 0000-0002-9622-2091
Adeola ObajemuLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Francis NkrumahNoguchi Memorial Institute, University of Ghana, Legon, Ghana.
Robert J BiggarInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Kishor BhatiaInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Allan Hildesheim *Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Denise L Doolan *Center for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.
Sam M Mbulaiteye *Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Cancer Genetics (United States) · USAustralian Institute of Tropical Health and Medicine · AUGeorge Washington University · USMoffitt Cancer Center · USNoguchi Memorial Institute for Medical Research · GHThe University of Queensland · AU

Funding

Epidemiology and Natural History of Cancer-Associated VirusesZIACP010176 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MBULAITEYE, SAM M · 2009 to 2025
$33.7M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

backgroundThe discovery of Epstein-Barr virus (EBV) in Burkitt lymphoma tumors represented the first link between a virus and cancer in humans, but the underlying role of this virus in endemic Burkitt lymphoma remains unclear. Nearly all children in Burkitt lymphoma-endemic areas are seropositive for EBV, but only a small percentage develop disease. Variation in EBV-directed immunity could be an explanatory cofactor.

methodsWe examined serum from 150 Burkitt lymphoma cases and 150 controls using a protein microarray that measured IgG and IgA antibodies against 202 sequences across the entire EBV proteome. Variation in the EBV-directed antibody repertoire between Burkitt lymphoma cases and controls was assessed using unpaired

resultsThirty-three anti-EBV IgG responses were elevated in Burkitt lymphoma cases compared with controls (

conclusionsOur data suggest that the anti-EBV serologic profile in patients with Burkitt lymphoma is altered, with strong elevations in 33 of the measured anti-EBV IgG antibodies relative to disease-free children. IMPACT: The Burkitt lymphoma-specific signature included EBV-based markers relevant for viral replication and antiapoptotic activity, providing clues for future Burkitt lymphoma pathogenesis research.

Indexed as

Endemic DiseasesAdolescentAntibodies, ViralAntigens, ViralApoptosisBurkitt LymphomaCase-Control StudiesChildChild, PreschoolEpstein-Barr Virus InfectionsFemaleGhanaHerpesvirus 4, HumanHumansInfantInfant, NewbornAntibodies, ViralAntigens, ViralViral Proteins

Identifiers

PMID31619404
PMCPMC6954331
OpenAlexW2981080713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.