Evidence map›Paper›PMID 31619294›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2019

The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy.

Marco A Mascarella, Lorne Schweitzer, Mahmoud Alreefi, Jennifer Silver, Derin Caglar, Vivian G Loo, Keith Richardson, Philippe Dufresne, Todd C Lee, Nader Sadeghi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Ibrutinib-associated cutaneous mucormycosis due to anTherapeutic advances in infectious disease
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Marco A MascarellaDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, Montreal, QC H4A 3 J1, Canada.ORCID http://orcid.org/0000-0002-8880-805X
Lorne SchweitzerDivision of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Canada.
Mahmoud AlreefiDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, Montreal, QC H4A 3 J1, Canada.
Jennifer SilverDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, Montreal, QC H4A 3 J1, Canada.
Derin CaglarDepartment of Pathology, McGill University Health Centre, Montreal, Canada.
Vivian G LooDivision of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Canada.
Keith RichardsonDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, Montreal, QC H4A 3 J1, Canada.
Philippe DufresneLaboratoire de Santé Publique du Québec, Sainte-Anne-de-Bellevue, Canada.
Todd C LeeDivision of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Canada.
Nader SadeghiDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, Montreal, QC H4A 3 J1, Canada. nader.sadeghi@mcgill.ca.
Royal Victoria Regional Health Centre · CAMcGill University Health Centre · CASte. Anne's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. CASE PRESENTATION: We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy.

conclusionPatients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck.

Indexed as

AdenineAgammaglobulinaemia Tyrosine KinaseAgedCunninghamellaHumansImmunocompromised HostLeukemia, Lymphocytic, Chronic, B-CellMaleMucormycosisPiperidinesPyrazolesPyrimidinesThyroid NoduleAdenineAgammaglobulinaemia Tyrosine KinaseBTK protein, humanibrutinibPiperidinesPyrazolesPyrimidinesAcute invasive fungal infectionIbrutinibMucormycosisThyroid nodule

Identifiers

PMID31619294
PMCPMC6794875
OpenAlexW2980736094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.