ArticleBMC plant biology2019
Inhibition of Polycomb Repressive Complex 2 activity reduces trimethylation of H3K27 and affects development in Arabidopsis seedlings.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- A DOF transcriptional repressor-gibberellin feedback loop plays a crucial role in modulating light-independent seed germination.Plant communications · 2025Article
- Plants and Small Molecules: An Up-and-Coming Synergy.Plants (Basel, Switzerland) · 2023Review
- Highlight Induced Transcriptional Priming against a Subsequent Drought Stress inInternational journal of molecular sciences · 2023Article
- Redox status of the plant cell determines epigenetic modifications under abiotic stress conditions and during developmental processes.Journal of advanced research · 2022Review
- New Inhibitors of the Human p300/CBP Acetyltransferase Are Selectively Active against the Arabidopsis HAC Proteins.International journal of molecular sciences · 2022Article
- Seed-to-Seedling Transition inPlants (Basel, Switzerland) · 2022Article
- Transition from Seeds to Seedlings: Hormonal and Epigenetic Aspects.Plants (Basel, Switzerland) · 2021Review
- Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells.Molecules (Basel, Switzerland) · 2020Article
- Phase separation of Arabidopsis EMB1579 controls transcription, mRNA splicing, and development.PLoS biology · 2020Article
- Multi-Omics Analysis Reveals Novel Subtypes and Driver Genes in Glioblastoma.Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPolycomb repressive complex 2 (PRC2) is an epigenetic transcriptional repression system, whose catalytic subunit (ENHANCER OF ZESTE HOMOLOG 2, EZH2 in animals) is responsible for trimethylating histone H3 at lysine 27 (H3K27me3). In mammals, gain-of-function mutations as well as overexpression of EZH2 have been associated with several tumors, therefore making this subunit a suitable target for the development of selective inhibitors. Indeed, highly specific small-molecule inhibitors of EZH2 have been reported. In plants, mutations in some PRC2 components lead to embryonic lethality, but no trial with any inhibitor has ever been reported.
resultsWe show here that the 1,5-bis (3-bromo-4-methoxyphenyl)penta-1,4-dien-3-one compound (RDS 3434), previously reported as an EZH2 inhibitor in human leukemia cells, is active on the Arabidopsis catalytic subunit of PRC2, since treatment with the drug reduces the total amount of H3K27me3 in a dose-dependent fashion. Consistently, we show that the expression level of two PRC2 targets is significantly increased following treatment with the RDS 3434 compound. Finally, we show that impairment of H3K27 trimethylation in Arabidopsis seeds and seedlings affects both seed germination and root growth.
conclusionsOur results provide a useful tool for the plant community in investigating how PRC2 affects transcriptional control in plant development.
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