Evidence map›Paper›PMID 31619095›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

A structure-based approach towards the identification of novel antichagasic compounds:

Manuel A Llanos, María L Sbaraglini, María L Villalba, María D Ruiz, Carolina Carrillo, Catalina Alba Soto, Alan Talevi, Andrea Angeli, Seppo Parkkila, Claudiu T Supuran and 1 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. A Computational Approach Using α-Carbonic Anhydrase to Find Anti-Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Inhibition studies of the protozoan α-carbonic anhydrase fromJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  8. Development of Praziquantel sulphonamide derivatives as antischistosomal drugs.Journal of enzyme inhibition and medicinal chemistry · 2022
    Article
  9. Review
  10. Review
  11. Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase fromInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manuel A LlanosLaboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , Buenos Aires , Argentina.
María L SbaragliniLaboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , Buenos Aires , Argentina.
María L VillalbaLaboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , Buenos Aires , Argentina.
María D RuizInstituto de Ciencias y Tecnología Dr. Cesar Milstein (ICT Milstein), Argentinean National Council of Scientific and Technical Research (CONICET) , Buenos Aires , Argentina.
Carolina CarrilloInstituto de Ciencias y Tecnología Dr. Cesar Milstein (ICT Milstein), Argentinean National Council of Scientific and Technical Research (CONICET) , Buenos Aires , Argentina.
Catalina Alba SotoDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM), UBA-CONICET , Buenos Aires , Argentina.
Alan TaleviLaboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , Buenos Aires , Argentina.
Andrea AngeliNeurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze , Sesto Fiorentino , Florence , Italy.ORCID 0000-0002-1470-7192
Seppo ParkkilaFaculty of Medicine and Health Technology, University of Tampere , Tampere , Finland.
Claudiu T SupuranNeurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze , Sesto Fiorentino , Florence , Italy.ORCID 0000-0003-4262-0323
Luciana GavernetLaboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , Buenos Aires , Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesChagas DiseaseCyclamatesDose-Response Relationship, DrugDrug Evaluation, PreclinicalHumansModels, MolecularMolecular StructureParasitic Sensitivity TestsStructure-Activity RelationshipTrypanocidal AgentsTrypanosoma cruziCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCyclamatesTrypanocidal Agentsacesulphamecarbonic anhydraseChagassodium cyclamatesulphamidesvirtual screening

Identifiers

PMID31619095
PMCPMC6807911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.