Evidence map›Paper›PMID 31619084›Full record

SynthesisEuropean journal of preventive cardiology2020

Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium.

Martin Bahls, Matthias W Lorenz, Marcus Dörr, Lu Gao, Kazuo Kitagawa, Tomi-Pekka Tuomainen, Stefan Agewall, Gerald Berenson, Alberico L Catapano, Giuseppe D Norata and 46 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of preventive cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

56 authors at 20 institutions in 15 countries.

Martin BahlsDepartment of Internal Medicine B, University Medicine Greifswald, Germany.
Matthias W LorenzDepartment of Neurology, Goethe University, Frankfurt am Main, Germany.
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Germany.
Lu GaoMRC Biostatistics Unit, Institute of Public Health, University Forvie Site, University of Cambridge, UK.
Kazuo KitagawaDepartment of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
Tomi-Pekka TuomainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Stefan AgewallInstitute of Clinical Sciences, University of Oslo, Oslo, Norway.
Gerald BerensonDepartment of Medicine, Pediatrics, Biochemistry, Epidemiology, Tulane University School of Medicine and School of Public Health and Tropical Medicine, New Orleans, USA.
Alberico L CatapanoIRCSS Multimedica, Milan, Italy.
Giuseppe D NorataDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Wiek van GilstDepartment of Experimental Cardiology, University Medical Center Groningen, The Netherlands.
Folkert W AsselbergsDepartment of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Frank P BrouwersDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
Heiko UthoffDepartment of Angiology, University Hospital Basel, Basel, Switzerland.
Dirk SanderDepartment of Neurology, Benedictus Hospital Tutzing, Tutzing, Germany.
Holger PoppertDepartment of Neurology, Technical University Munich, Munich, Germany.
Michael Hecht OlsenDepartment of Internal Medicine, Holbaek Hospital and Institute of Regional Health Research, University of Southern Denmark, Denmark.
Jean Philippe EmpanaUniversité de Paris, INSERM U970, Paris Cardiovascular Research Centre, Paris, France.
Ulf SchminkeDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Damiano BaldassarreCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Fabrizio VegliaCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Maryam KavousiDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Eric de GrootImagelabonline and Cardiovascular, Erichem, The Netherlands.
Ellisiv B MathiesenDepartment of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Liliana GrigoreCentro Sisa per lo Studio della Aterosclerosi, Bassini Hospital, Cinisello Balsamo, Italy.
Joseph F PolakTufts University School of Medicine, Tufts Medical Center, Boston, USA.
Tatjana RundekDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, USA.
Coen DA StehouwerDepartment of Internal Medicine and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands.
Michael R SkiltonThe Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, Australia.
Apostolos I HatzitoliosPropedeutic Department of Internal Medicine, Aristotle University of Thessaloniki - AHEPA Hospital, Greece.
Christos SavopoulosPropedeutic Department of Internal Medicine, Aristotle University of Thessaloniki - AHEPA Hospital, Greece.
George NtaiosDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Matthieu PlichartCentro Sisa per lo Studio della Aterosclerosi, Bassini Hospital, Cinisello Balsamo, Italy.
Stela McLachlanUsher Institute, University of Edinburgh, Edinburgh, UK.
Lars LindDepartment of Medicine, Uppsala University, Uppsala, Sweden.
Peter WilleitDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Helmuth SteinmetzDepartment of Neurology, Goethe University, Frankfurt am Main, Germany.
Moise DesvarieuxDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Stein Harald JohnsenDepartment of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Caroline SchmidtDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden.
Johann WilleitDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Pierre DucimetiereUniversity Paris Sud Xi, Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
Jackie F PriceUsher Institute, University of Edinburgh, Edinburgh, UK.
Göran BergströmDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden.
Jussi KauhanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Stefan KiechlDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Matthias SitzerDepartment of Neurology, Goethe University, Frankfurt am Main, Germany.
Horst BickelDepartment of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.
Ralph L SaccoDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, USA.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Henry VölzkeGerman Centre for Cardiovascular Research (DZHK), partner site Greifswald, Germany.
Simon G ThompsonDepartment of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
PROG-IMT Study Group
Erasmus MC · NLGerman Centre for Cardiovascular Research · DEAHEPA University Hospital · GRGoethe University Frankfurt · DEInnsbruck Medical University · ATOspedale Bassini · ITTechnical University of Munich · DEUniversity Medical Center Groningen · NLUniversity of Cambridge · GBUniversity of Eastern Finland · FIUniversity of Edinburgh · GBUniversity of Miami · USBicêtre Hospital · FRCentro Cardiologico Monzino · ITHerford Hospital · DEHôpital Broca · FRInserm · FRInstitute of Social and Preventive Medicine · CHMaastricht University Medical Centre · NLMRC Biostatistics Unit · GB

Funding

Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
Genetics Determinants of Extreme Phenotypes of Subclinical AtherosclerosisK24NS062737 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA · 2009 to 2013
$975k
NHLBI NIH HHS HHSN268201200036CNINDS NIH HHS K24 NS062737NINDS NIH HHS R37 NS029993
6 · The paper itself

Abstract

aimsAveraged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. METHODS AND

resultsAn individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (

conclusionAveraged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.

Indexed as

Blood PressureCardiovascular DiseasesCarotid Artery DiseasesCholesterolDyslipidemiasHypertensionAdultAgedAged, 80 and overBiomarkersCarotid Intima-Media ThicknessCholesterol, HDLCholesterol, LDLDisease ProgressionFemaleHeart Disease Risk FactorsBiomarkersCholesterolCholesterol, HDLCholesterol, LDLCVD biomarkerrisk factor progressionRisk factors

Identifiers

PMID31619084
PMCPMC7008553
OpenAlexW2980473336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.