Evidence map›Paper›PMID 31619063›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

Short AIP1 (ASK1-Interacting Protein-1) Isoform Localizes to the Mitochondria and Promotes Vascular Dysfunction.

Zheng Li, Li Li, Haifeng Zhang, Huanjiao Jenny Zhou, Weidong Ji, Wang Min

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Vascular Endothelial Cells and Innate Immunity.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  10. Epigenetic Control of Mitochondrial Function in the Vasculature.Frontiers in cardiovascular medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zheng LiFrom the Vascular Biology and Therapeutics Program, Department of Pathology, Yale University School of Medicine, New Haven, CT (Z.L., L.L., H.Z., H.J.Z., W.M.).
Li LiFrom the Vascular Biology and Therapeutics Program, Department of Pathology, Yale University School of Medicine, New Haven, CT (Z.L., L.L., H.Z., H.J.Z., W.M.).
Haifeng ZhangFrom the Vascular Biology and Therapeutics Program, Department of Pathology, Yale University School of Medicine, New Haven, CT (Z.L., L.L., H.Z., H.J.Z., W.M.).
Huanjiao Jenny ZhouFrom the Vascular Biology and Therapeutics Program, Department of Pathology, Yale University School of Medicine, New Haven, CT (Z.L., L.L., H.Z., H.J.Z., W.M.).
Weidong JiCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (L.L., W.J.).
Wang MinFrom the Vascular Biology and Therapeutics Program, Department of Pathology, Yale University School of Medicine, New Haven, CT (Z.L., L.L., H.Z., H.J.Z., W.M.).
Yale University · US

Funding

The role of signaling molecule AIP1 in pathological angiogenesisR01HL115148 · NHLBI · YALE UNIVERSITY · PI KYRIAKIDES, THEMIS R · 2013 to 2021
$3.6M
STRESS SIGNALING PATHWAYS LINKING ENDOTHELIAL INJURY TO GRAFT ARTERIOSCLEROSISR01HL109420 · NHLBI · YALE UNIVERSITY · PI POBER, JORDAN S · 2012 to 2020
$3.3M
NHLBI NIH HHS R01 HL109420NHLBI NIH HHS R01 HL115148
6 · The paper itself

Abstract

objectiveVascular endothelial cells (ECs) normally maintain vascular homeostasis and are regulated by proinflammatory cytokines and reactive oxygen species. A human genome-wide association study identified that

conclusionsOur current study suggests that a shift from anti-inflammatory AIP1A to proinflammatory AIP1B during chronic inflammation plays a key role in inflammatory vascular diseases.

Indexed as

Gene Expression RegulationAnimalsAorta, ThoracicApoptosisArteriosclerosisBlotting, WesternCells, CulturedDisease Models, AnimalDNAEndothelium, VascularGenome-Wide Association StudyHumansMiceMice, Inbred C57BLMice, TransgenicMicroscopy, FluorescenceDAB2IP protein, humanDNAras GTPase-Activating Proteinsanimalsaortaatherosclerosisepigenomicsmice

Identifiers

PMID31619063
PMCPMC7204498
OpenAlexW2980765227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.