Evidence map›Paper›PMID 31619022›Full record

ArticleNutrients2019

Lifelong n-3 Polyunsaturated Fatty Acid Exposure Modulates Size of Mammary Epithelial Cell Populations and Expression of Caveolae Resident Proteins in Fat-1 Mice.

Lyn M Hillyer, Jing X Kang, David W L Ma

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lyn M HillyerDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. lhillyer@uoguelph.ca.
Jing X KangMassachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. kang.jing@mgh.harvard.edu.
David W L MaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. davidma@uoguelph.ca.
University of Guelph · CAHarvard University · US

Funding

Natural Sciences and Engineering Research Council of Canada #06018
6 · The paper itself

Abstract

Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been associated with reduced breast cancer risk; however, the exact mechanism remains elusive. Female wildtype (WT) and fat-1 mice were fed a 10% safflower diet until 6 weeks of age. Mammary gland epithelial cells (EC) were isolated and EC populations were determined by CD24 surface expression. Fat-1 mice expressed 65%, 20%, and 15% while WT mice expressed 65%, 26% and 9% for non-, myo- and luminal ECs, respectively. The luminal EC population was significantly greater in fat-1 mice (

Indexed as

Dietary SupplementsAnimalsBreast NeoplasmsCaenorhabditis elegans ProteinsCaveolaeCaveolin 1CD24 AntigenEpithelial CellsErb-b2 Receptor Tyrosine KinasesEstrogen Receptor alphaFatty Acid DesaturasesFatty Acids, Omega-3FemaleMammary Glands, AnimalMice, TransgenicPhenotypeCaenorhabditis elegans ProteinsCav1 protein, mouseCaveolin 1CD24 AntigenCd24a protein, mouseErbb2 protein, mouseErb-b2 Receptor Tyrosine KinasesEsr1 protein, mouseEstrogen Receptor alphafat-1 protein, C elegansFatty Acid DesaturasesFatty Acids, Omega-3breast cancercaveolaeER-αfat-1 miceHer-2/neun-3 PUFA

Identifiers

PMID31619022
PMCPMC6835466
OpenAlexW2980847798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.