Evidence map›Paper›PMID 31618917›Full record

ArticleInternational journal of molecular sciences2019

Genome-Wide Adductomics Analysis Reveals Heterogeneity in the Induction and Loss of Cyclobutane Thymine Dimers across Both the Nuclear and Mitochondrial Genomes.

Alaa S Alhegaili, Yunhee Ji, Nicolas Sylvius, Matthew J Blades, Mahsa Karbaschi, Helen G Tempest, George D D Jones, Marcus S Cooke

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Genome-wide mapping of genomic DNA damage: methods and implications.Cellular and molecular life sciences : CMLS · 2021
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alaa S AlhegailiOxidative Stress Group, University of Leicester, Leicester LE1 9HN, UK. a.alhegaili@psau.edu.sa.
Yunhee JiPresent Addresses: Oxidative Stress Group, Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA. yji008@fiu.edu.ORCID 0000-0002-3814-382X
Nicolas SylviusNUCLEUS Genomics, Core Biotechnology Services, University of Leicester, Leicester LE1 9HN, UK. ns249@leicester.ac.uk.
Matthew J BladesBioinformatics and Biostatistics Analysis Support Hub (BBASH), Core Biotechnology Services, University of Leicester, Leicester LE1 9HN, UK. mb492@leicester.ac.uk.
Mahsa KarbaschiOxidative Stress Group, University of Leicester, Leicester LE1 9HN, UK. mkarbasc@fiu.edu.
Helen G TempestPresent Addresses: Department of Human Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. htempest@fiu.edu.ORCID 0000-0002-2369-4127
George D D JonesRadiobiology & DNA Damage Group, Leicester Cancer Research Centre, University of Leicester, Leicester LE1 9HN, UK. gdj2@le.ac.uk.
Marcus S CookeOxidative Stress Group, University of Leicester, Leicester LE1 9HN, UK. mcooke@fiu.edu.ORCID 0000-0003-0369-862X

Funding

Genomic instability, susceptibility to oxidative stress and cellular senescenceR15ES027196 · NIEHS · FLORIDA INTERNATIONAL UNIVERSITY · PI COOKE, MARCUS STANLEY · 2017 to 2017
$366k
AHTP-comet: development of an automated, high throughput comet assay systemR41ES030274 · NIEHS · ENGINEERING RESOURCES GROUP, INC. · PI COOKE, MARCUS STANLEY, ROSS, CHRISTOPHER · 2019 to 2019
$150k
NIEHS NIH HHS R15 ES027196NIEHS NIH HHS R15ES027196NIEHS NIH HHS R41 ES030274Prince Sattam bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia Studentship
6 · The paper itself

Abstract

The distribution of DNA damage and repair is considered to occur heterogeneously across the genome. However, commonly available techniques, such as the alkaline comet assay or HPLC-MS/MS, measure global genome levels of DNA damage, and do not reflect potentially significant events occurring at the gene/sequence-specific level, in the nuclear or mitochondrial genomes. We developed a method, which comprises a combination of Damaged DNA Immunoprecipitation and next generation sequencing (DDIP-seq), to assess the induction and repair of DNA damage induced by 0.1 J/cm

Indexed as

Genetic HeterogeneityGenomeGenome, MitochondrialGenome-Wide Association StudyCell SurvivalCyclobutanesDNA DamageDNA RepairHigh-Throughput Nucleotide SequencingPyrimidine DimersCyclobutanesPyrimidine DimersDNA damageDNA repairgenome analysisnext generation sequencingUV radiation

Identifiers

PMID31618917
PMCPMC6834194

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.