Evidence map›Paper›PMID 31618877›Full record

ArticleNutrients2019

A New Calcium Oral Controlled-Release System Based on Zeolite for Prevention of Osteoporosis.

Angela Fabiano, Anna Maria Piras, Vincenzo Calderone, Lara Testai, Lorenzo Flori, Dario Puppi, Federica Chiellini, Ylenia Zambito

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Pharmaceutically engineered olfactory-masking agents: Innovating oral drug delivery through multisensory excipient design.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  3. Zeolites: A series of promising biomaterials in bone tissue engineering.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Angela FabianoDepartment of Pharmacy, University of Pisa, via Bonanno 33, 56126 Pisa, Italy. angela.fabiano@unipi.it.
Anna Maria PirasDepartment of Pharmacy, University of Pisa, via Bonanno 33, 56126 Pisa, Italy. anna.piras@unipi.it.ORCID 0000-0002-4082-6400
Vincenzo CalderoneDepartment of Pharmacy, University of Pisa, via Bonanno 33, 56126 Pisa, Italy. vincenzo.calderone@unipi.it.
Lara TestaiDepartment of Pharmacy, University of Pisa, via Bonanno 33, 56126 Pisa, Italy. lara.testai@unipi.it.ORCID 0000-0003-2431-6248
Lorenzo FloriDepartment of Pharmacy, University of Pisa, via Bonanno 33, 56126 Pisa, Italy. lorenzoflori17@gmail.com.
Dario PuppiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Udr INSTM Pisa, Via Moruzzi 13, 56124 Pisa, Italy. dario.puppi@unipi.it.ORCID 0000-0002-9251-4388
Federica ChielliniDepartment of Chemistry and Industrial Chemistry, University of Pisa, Udr INSTM Pisa, Via Moruzzi 13, 56124 Pisa, Italy. federica.chiellini@unipi.it.
Ylenia ZambitoDepartment of Pharmacy, University of Pisa, via Bonanno 33, 56126 Pisa, Italy. ylenia.zambito@unipi.it.ORCID 0000-0003-0064-233X
University of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis, a systemic skeleton disease, can be prevented by increasing calcium levels in serum via administration of calcium salts. However, traditional calcium-based formulations have not appeared to be effective, hence the purpose of the present work has been to prepare and test in vitro/vivo a formulation able to gradually release calcium during transit over the GI tract, thus increasing bioavailability and reducing daily dose, and hence, side effects. Calcium controlled-release granules based on zeolite and Precirol

Indexed as

Administration, OralAnimalsBiomarkersBone Density Conservation AgentsBone RemodelingCalcium ChlorideDelayed-Action PreparationsDiglyceridesDisease Models, AnimalDrug CarriersDrug CompoundingDrug LiberationFemurHumansOsteocalcinOsteoporosis, PostmenopausalBiomarkersBone Density Conservation AgentsCalcium ChlorideclinoptiloliteDelayed-Action PreparationsDiglyceridesDrug CarriersOsteocalcinprecirolZeolitesCalcium controlled releasecalcium zeolitefemur mechanical characterizationfemur morphological characterizationosteopenic ratsPrecirol® granules

Identifiers

PMID31618877
PMCPMC6835288
OpenAlexW2981292251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.