Evidence map›Paper›PMID 31618846›Full record

ArticleMolecules (Basel, Switzerland)2019

The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity.

Urszula Tałałaj, Paulina Uścinowicz, Irena Bruzgo, Arkadiusz Surażyński, Ilona Zaręba, Agnieszka Markowska

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.Journal of peptide science : an official publication of the European Peptide Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Urszula TałałajDepartment of Organic Chemistry, Medical University of Białystok, Białystok 15-089, Poland. talalaj.urszula@gmail.com.
Paulina UścinowiczDepartment of Organic Chemistry, Medical University of Białystok, Białystok 15-089, Poland. paulina.uscinowicz@umb.edu.pl.
Irena BruzgoDepartment of Organic Chemistry, Medical University of Białystok, Białystok 15-089, Poland. irena.bruzgo@umb.edu.pl.
Arkadiusz SurażyńskiDepartment of Medicinal Chemistry, Medical University of Białystok, Białystok 15-089, Poland. arkadiusz.surazynski@umb.edu.pl.
Ilona ZarębaDepartment of Medicinal Chemistry, Medical University of Białystok, Białystok 15-089, Poland. ilona.zareba@onet.eu.
Agnieszka MarkowskaDepartment of Organic Chemistry, Medical University of Białystok, Białystok 15-089, Poland. agnieszka.markowska@umb.edu.pl.ORCID 0000-0001-8685-5699

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KTTKS is a matrikine that originates from the proteolytic hydrolysis of collagen. This peptide stimulates ECM production and types I and III collagen expression in vitro. A more stable form of KTTKS is pal-KTTKS, known as Matrixyl

Indexed as

Cells, CulturedCell SurvivalCollagenFibroblastsInhibitory Concentration 50OligopeptidesPeptidesProteolysisCollagenOligopeptidespalmitoyl-lysyl-threonyl-threonyl-lysyl-serinePeptidescollagen biosynthesiscosmetic peptidescytotoxityKTTKSpalmitoyl pentapeptideplasmin inhibitors

Identifiers

PMID31618846
PMCPMC6832239

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.