ReviewInternational journal of molecular sciences2019
Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 79 citations in OpenAlex.
- A Phase IIb Randomized Controlled Trial Investigating the Effects of Tocotrienol-Rich Vitamin E on Diabetic Kidney Disease.Nutrients · 2021Trial
- Antioxidative Japanese herbal medicine formula prevents diabetic renal complications.Journal of natural medicines · 2026Article
- Optimization of Bioactive Lipid Synthesis by Enzymatic Acidolysis Using EPA + DHA Concentrate from Rainbow Trout and Tocopherols from Maqui Seed Oil.Foods (Basel, Switzerland) · 2026Article
- Review
- Exploring the impact of physical activity and micronutrients on diabetic nephropathy: a subtype-specific genetic correlation and Mendelian randomization study.Nutrition & metabolism · 2025Article
- Green Leafy Vegetables (GLVs) as Nutritional and Preventive Agents Supporting Metabolism.Metabolites · 2025Review
- Unlocking the Potential of Freeze-Dried Broccoli Powder: A Novel Approach to Enhancing Cognitive Resilience in Temporal Lobe Epilepsy.Food science & nutrition · 2025Article
- Effect of Vitamin E on Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.International journal of molecular sciences · 2025Article
- Tocochromanols in the Leaves of Plants in theMolecules (Basel, Switzerland) · 2025Article
- Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats.Journal of toxicology · 2025Article
- Evaluation of flavonoid composition and biological activities of hydrolyzed whole pomelo juice.Frontiers in nutrition · 2025Article
- Supplementation of Antioxidants in Chronic Kidney Disease: Clinical Necessity or Wishful Thinking? A Bench to Bedside Translational Research.Current medicinal chemistry · 2025Review
- Serum Vitamin E Status in Patients With Type 2 Diabetes Mellitus Among Bangladeshi Population.Global health, epidemiology and genomics · 2025Article
- Effect ofInternational journal of molecular sciences · 2024Article
- Causal relationships between vitamin E and multiple kidney diseases: evidence from trans-ethnic Mendelian randomization study.European journal of nutrition · 2024Article
- Overview of oxidative stress and inflammation in diabetes.Journal of diabetes · 2024Review
- Article
- Combination Therapy for Sustainable Fish Oil Products: Improving Cognitive Function with n-3 PUFA and Natural Ingredients.Biomedicines · 2024Review
- Modification of Preservative Fluids with Antioxidants in Terms of Their Efficacy in Liver Protection before Transplantation.International journal of molecular sciences · 2024Review
- Evaluation of plasma vitamin E and development of proteinuria in hypertensive patients.Journal of translational internal medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is a metabolic disorder characterized by the development of vascular complications associated with high morbidity and mortality and the consequent relevant costs for the public health systems. Diabetic kidney disease is one of these complications that represent the main cause of end-stage renal disease in Western countries. Hyperglycemia, inflammation, and oxidative stress contribute to its physiopathology, and several investigations have been performed to evaluate the role of antioxidant supplementation as a complementary approach for the prevention and control of diabetes and associated disturbances. Vitamin E compounds, including different types of tocopherols and tocotrienols, have been considered as a treatment to tackle major cardiovascular outcomes in diabetic subjects, but often with conflicting or even negative results. However, their effects on diabetic nephropathy are even less clear, despite several intervention studies that showed the improvement of renal parameters after supplementation in patients with diabetic kidney disease. Then we performed a review of the literature about the role of vitamin E supplementation on diabetic nephropathy, also describing the underlying antioxidant, anti-inflammatory, and metabolic mechanisms to evaluate the possible use of tocopherols and tocotrienols in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.