Evidence map›Paper›PMID 31618649›Full record

ArticleImmunity2019

Renal Function: Guardian of Immune Homeostasis.

Katja Brückner

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Katja BrücknerEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: katja.brueckner@ucsf.edu.
University of California, San Francisco · US

Funding

Regulation of cell signaling and developmental adaptation by sensory stimulationR01GM112083 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUECKNER, KATJA · 2014 to 2018
$1.5M
Molecular mechanisms of a multi-tissue innate immune responseR01GM131094 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JONES, DANA LEANNE · 2019 to 2022
$1.4M
Mechanisms of hematopoietic regulation by the nervous systemR56HL118726 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUECKNER, KATJA · 2014 to 2014
$395k
NHLBI NIH HHS R56 HL118726NIGMS NIH HHS R01 GM112083NIGMS NIH HHS R01 GM131094
6 · The paper itself

Abstract

Microbial cell components from the intestinal microbiota spread systemically in a healthy host, posing the threat of inappropriate immune activation. In this issue of Immunity, Troha et al. identify a key role for renal function in the clearance of circulating Lys-type peptidoglycan, revealing a mechanism that keeps these inflammatory triggers in check to maintain systemic immune homeostasis.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaHomeostasisImmunityPeptidoglycanPeptidoglycan

Identifiers

PMID31618649
PMCPMC8575130
OpenAlexW2980569777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.