Evidence map›Paper›PMID 31618632›Full record

ArticleCell reports2019

Synaptic Specializations of Melanopsin-Retinal Ganglion Cells in Multiple Brain Regions Revealed by Genetic Label for Light and Electron Microscopy.

Keun-Young Kim, Luis C Rios, Hiep Le, Alex J Perez, Sébastien Phan, Eric A Bushong, Thomas J Deerinck, Yu Hsin Liu, Maya A Ellisman, Varda Lev-Ram and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

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  9. OPA1 Dominant Optic Atrophy: Pathogenesis and Therapeutic Targets.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Keun-Young KimDepartment of Neurosciences, University of California at San Diego School of Medicine, La Jolla, CA, USA; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Luis C RiosSalk Institute for Biological Studies, La Jolla, CA, USA.
Hiep LeSalk Institute for Biological Studies, La Jolla, CA, USA.
Alex J PerezNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Sébastien PhanDepartment of Neurosciences, University of California at San Diego School of Medicine, La Jolla, CA, USA; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Eric A BushongDepartment of Neurosciences, University of California at San Diego School of Medicine, La Jolla, CA, USA; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Thomas J DeerinckDepartment of Neurosciences, University of California at San Diego School of Medicine, La Jolla, CA, USA; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Yu Hsin LiuSalk Institute for Biological Studies, La Jolla, CA, USA; Medical Scientist Training Program, University of California at San Diego School of Medicine, La Jolla, CA, USA.
Maya A EllismanBiological Sciences Graduate Training Program, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Varda Lev-RamDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Suyeon JuNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Sneha A PandaNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Sanghee YoonNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Masatoshi HirayamaSalk Institute for Biological Studies, La Jolla, CA, USA.
Ludovic S MureSalk Institute for Biological Studies, La Jolla, CA, USA.
Megumi HatoriSalk Institute for Biological Studies, La Jolla, CA, USA.
Mark H EllismanDepartment of Neurosciences, University of California at San Diego School of Medicine, La Jolla, CA, USA; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. Electronic address: mellisman@ucsd.edu.
Satchidananda PandaSalk Institute for Biological Studies, La Jolla, CA, USA. Electronic address: satchin@salk.edu.
University of California San Diego · USSalk Institute for Biological Studies · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
IVEM and Image Analysis ResourceP41GM103412 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2012 to 2019
$17.9M
New Probe and Methods for Correlated LM & EMR01GM086197 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADAMS, STEPHEN ROY, BOASSA, DANIELA · 2008 to 2020
$8.3M
Circadian Photoentrainment in MammalsR01EY016807 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PANDA, SATCHIDANANDA · 2007 to 2019
$6.4M
DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONSR01NS027177 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADAMS, STEPHEN ROY, ELLISMAN, MARK H · 1989 to 2017
$5.8M
NEI NIH HHS R01 EY016807NIGMS NIH HHS P41 GM103412NIGMS NIH HHS R01 GM086197NINDS NIH HHS R01 NS027177
6 · The paper itself

Abstract

The form and synaptic fine structure of melanopsin-expressing retinal ganglion cells, also called intrinsically photosensitive retinal ganglion cells (ipRGCs), were determined using a new membrane-targeted version of a genetic probe for correlated light and electron microscopy (CLEM). ipRGCs project to multiple brain regions, and because the method labels the entire neuron, it was possible to analyze nerve terminals in multiple retinorecipient brain regions, including the suprachiasmatic nucleus (SCN), olivary pretectal nucleus (OPN), and subregions of the lateral geniculate. Although ipRGCs provide the only direct retinal input to the OPN and SCN, ipRGC terminal arbors and boutons were found to be remarkably different in each target region. A network of dendro-dendritic chemical synapses (DDCSs) was also revealed in the SCN, with ipRGC axon terminals preferentially synapsing on the DDCS-linked cells. The methods developed to enable this analysis should propel other CLEM studies of long-distance brain circuits at high resolution.

Indexed as

AnimalsAxonsBrainCircadian RhythmFemaleMaleMelanopsinMiceMice, KnockoutMicroscopy, ElectronPretectal RegionRetinal Ganglion CellsRod OpsinsSuprachiasmatic NucleusSynapsesMelanopsinRod OpsinscircadianIGLipRGCLGNmelanopsinminiSOGmRGCOPNSCNserial blockface electron microscopy

Identifiers

PMID31618632
PMCPMC7045601
OpenAlexW2981061399

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.