Evidence map›Paper›PMID 31618602›Full record

ReviewAnnual review of physiology2020

BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract.

Yongchun Zhang, Jianwen Que

Abstract readReview
In one paragraph

Review in Annual review of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 85 citations in OpenAlex.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yongchun ZhangDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA; email: jq2240@cumc.columbia.edu.
Jianwen QueDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA; email: jq2240@cumc.columbia.edu.
Columbia University · US

Funding

Basal Progenitor Cells and Eosinophilic EsophagitisR01DK100342 · NIDDK · UNIVERSITY OF ROCHESTER · PI QUE, JIANWEN · 2014 to 2022
$3.3M
Nkx2.1+ Lung-Derived Cells in Asthma and Eosinophilic Esophagitis (EoE)R01HL132996 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2017 to 2020
$2.0M
VEGF/KDR Signaling in Airway Epithelial Regeneration and DiseaseR01HL152293 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.0M
Signaling Mechanisms Promoting Barrett’s MetaplasiaR01DK120650 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2019 to 2022
$1.8M
Barrett's esophagus and progenitor cells at the squamous-columnar junctionR01DK113144 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2017 to 2020
$1.4M
NHLBI NIH HHS R01 HL132996NHLBI NIH HHS R01 HL152293NIDDK NIH HHS R01 DK100342NIDDK NIH HHS R01 DK113144NIDDK NIH HHS R01 DK120650
6 · The paper itself

Abstract

The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in the digestive system. Abnormal BMP signaling has also been associated with disease initiation and progression in the gastrointestinal (GI) tract and associated organs. Recent studies using animal models, tissue organoids, and human pluripotent stem cells have significantly expanded our understanding of the roles played by BMPs in the development and homeostasis of GI organs. It is clear that BMP signaling regulates GI function and disease progression that involve stem/progenitor cells and inflammation in a tissue-specific manner. In this review we discuss these new findings with a focus on the esophagus, stomach, and intestine.

Indexed as

Bone Morphogenetic ProteinsSignal TransductionAnimalsGastrointestinal DiseasesGastrointestinal TractHumansStem CellsBone Morphogenetic Proteinscancerepithelium-mesenchymal interactionesophagusintestinestomachTGF-β superfamily

Identifiers

PMID31618602
PMCPMC13090088
OpenAlexW2981301051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.