Observational studyPloS one2019
Longitudinal trends of and factors associated with inappropriate antibiotic prescribing for non-bacterial acute respiratory tract infection in Japan: A retrospective claims database study, 2012-2017.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Appropriateness of outpatient antibiotic prescriptions in acute-care hospitals in Japan: a cross-sectional study from 2016-22.JAC-antimicrobial resistance · 2026Article
- Impact of National Policies Promoting Appropriate Antibiotic Use on Outpatient Prescriptions and Hospitalizations for Bacterial Complications of Acute Respiratory Infections in Japan: An Interrupted Time-Series Analysis.Open forum infectious diseases · 2026Article
- Unbeneficial effects of not prescribing antibiotics to pediatric patients with acute upper respiratory infection: a descriptive epidemiological study based on a large Japanese medical claim database.Journal of pharmaceutical health care and sciences · 2025Article
- Days of Antibiotic Spectrum Coverage (DASC) and Oral Antimicrobial-Use Trends at a Community Pharmacy in Japan: A 2018-2023 Retrospective Observational Study.Antibiotics (Basel, Switzerland) · 2025Article
- Impact of education on antibiotic literacy and awareness among pharmacy students at a Japanese university: a questionnaire survey.Journal of pharmaceutical health care and sciences · 2025Article
- Association of patient, physician and visit characteristics with inappropriate antibiotic prescribing in Japanese primary care: a cross-sectional study.BMJ public health · 2025Article
- Prescribing antibiotics for children with dengue infection in Taiwan: who are at risk and who are high prescribers?International journal for quality in health care : journal of the International Society for Quality in Health Care · 2024Article
- Antibiotic use and consumption among medical patients of two hospitals in Sierra Leone: a descriptive report.BMC infectious diseases · 2023Article
- Surveillance of Antimicrobial Prescriptions in Community Pharmacies Located in Tokyo, Japan.Antibiotics (Basel, Switzerland) · 2023Article
- A scoping review and behavioural analysis of factors underlying overuse of antimicrobials.JAC-antimicrobial resistance · 2023Article
- Prescription factors influencing baloxavir prescription during the 2018/2019 and 2019/2020 seasons: a administrative database study in Japan.Journal of pharmaceutical health care and sciences · 2023Article
- Prescribed daily-dose-based metrics of oral antibiotic use for hospitalized children in Japan.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Investigation of oral macrolide prescriptions in Japan using a retrospective claims database, 2013-2018.PloS one · 2023Review
- Outpatient antibiotic prescribing for acute respiratory infections in Vietnamese primary care settings by the WHO AWaRe (Access, Watch and Reserve) classification: An analysis using routinely collected electronic prescription data.The Lancet regional health. Western Pacific · 2023Article
- Coping with 'the grey area' of antibiotic prescribing: a theory-informed qualitative study exploring family physician perspectives on antibiotic prescribing.BMC primary care · 2022Article
- Population-based assessment of factors influencing antibiotic prescribing for adults with dengue infection in Taiwan.PLoS neglected tropical diseases · 2022Article
- Outcomes and Future Prospect of Japan's National Action Plan on Antimicrobial Resistance (2016-2020).Antibiotics (Basel, Switzerland) · 2021Review
- Trends in healthcare visits and antimicrobial prescriptions for acute infectious diarrhea in individuals aged 65 years or younger in Japan from 2013 to 2018 based on administrative claims database: a retrospective observational study.BMC infectious diseases · 2021Observational
- Narrative Review: The Process of Expanding the Manual of Antimicrobial Stewardship by the Government of Japan.Internal medicine (Tokyo, Japan) · 2021Review
- Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInappropriate antibiotic prescribing is a cause of antimicrobial resistance. Acute Respiratory Tract Infections (ARTI) are common diseases for those antibiotics are most likely prescribed in outpatient setting.
objectivesTo clarify factors associated with antibiotic prescribing for non-bacterial acute respiratory tract infections (NB-ARTI) and identify targets for reducing inappropriate prescribing for NB-ARTI in Japan.
methodsWe conducted a retrospective, observational study using longitudinal claims data between April 2012 and June 2017. We assessed the rate of and factors associated with inappropriate antibiotic prescribing in outpatient settings for all NB-ARTI consultations included in the database.
resultsThe mean monthly antibiotic prescribing rate per 100 NB-ARTI consultations during the study period was 31.65. The monthly antibiotic prescribing rate per 100 NB-ARTI consultations decreased by 19.2% from April 2012 to June 2017. Adolescents (13-18 years) and adults of working age (19-29 and 30-39 years) were more likely prescribed antibiotics compared with elderly patients ≥ 60 years (aOR: 1.493 [95%CI: 1.482-1.503], 1.585 [95%CI: 1.575-1.595], and 1.507 [95%CI: 1.498-1.516], respectively). Outpatient clinics registered as internal medicine or ear, nose, and throat specialty were more likely to prescribe antibiotics than those of paediatric specialty or other specialties. Among health facility type, clinics without beds (aOR 2.123 [95%CI: 2.113-2.133]) and clinics with beds (aOR: 1.752 [95%CI: 1.7371-1.767]) prescribed significantly more antibiotics for NB-ARTI than outpatient departments inside general hospitals.
conclusionsInappropriate antibiotic prescribing for NB-ARTI is common in Japan. Although the antibiotic prescribing rate has decreased, further interventions are required to promote antimicrobial stewardship (ASP). Education and awareness for adults and promotion of ASP among physicians in clinics without beds are key drivers to reduce inappropriate antibiotic prescribing in Japan.
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